K
Ke Shang
Researcher at Huazhong University of Science and Technology
Publications - 28
Citations - 5273
Ke Shang is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 7, co-authored 15 publications receiving 3255 citations.
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Journal ArticleDOI
Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China.
Chuan Qin,Luoqi Zhou,Ziwei Hu,Shuo-Qi Zhang,Sheng Yang,Yu Tao,Cuihong Xie,Ke Ma,Ke Shang,Wei Wang,Dai Shi Tian +10 more
TL;DR: Investigation of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of COVID-19 and shows the novel coronavirus might mainly act on lymphocytes, especially T lymphocytes.
Journal ArticleDOI
Dysregulation of Immune Response in Patients with COVID-19 in Wuhan, China
Chuan Qin,Luoqi Zhou,Ziwei Hu,Shuo-Qi Zhang,Sheng Yang,Yu Tao,Cuihong Xie,Ke Ma,Ke Shang,Wei Wang,Dai-Shi Tian +10 more
TL;DR: Patients with COVID-19 have lower level of regulatory T cells, and more obviously damaged in severe cases, compared with non-severe patients, which suggests surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of CO VID-19.
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Coronavirus Disease 2019 (COVID-2019) Infection Among Health Care Workers and Implications for Prevention Measures in a Tertiary Hospital in Wuhan, China.
Xiaoquan Lai,Minghuan Wang,Chuan Qin,Li Tan,Lusen Ran,Daiqi Chen,Han Zhang,Ke Shang,Chen Xia,Wang Shaokang,Shabei Xu,Wei Wang +11 more
TL;DR: In this study, most infections among health care workers occurred during the early stage of the COVID-19 outbreak and in low-contagion areas; routine screening may be helpful in identifying asymptomatic carriers.
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Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway.
Chuan Qin,Wen Hui Fan,Qian Liu,Ke Shang,Madhuvika Murugan,Madhuvika Murugan,Long Jun Wu,Wei Wang,Dai Shi Tian +8 more
TL;DR: Interestingly, FTY720 could reduce cognitive decline and ameliorate the disruption of WM integrity, a potential therapeutic drug targeting brain inflammation by skewing microglia toward M2 polarization after chronic cerebral hypoperfusion.
Journal ArticleDOI
Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway.
Chuan Qin,Qian Liu,Zi Wei Hu,Luo Qi Zhou,Ke Shang,Dale B. Bosco,Long Jun Wu,Dai Shi Tian,Wei Wang +8 more
TL;DR: TLR4-dependent autophagy regulates microglial polarization and induces ischemic white matter damage via STAT1/6 pathway, and TLR4 deficiency could mimic the phenomenon in microglia functional transformation, and exhibit a protective activity in chronic cerebral hypoperfusion.