K
Keejung Yoon
Researcher at Sungkyunkwan University
Publications - 71
Citations - 5329
Keejung Yoon is an academic researcher from Sungkyunkwan University. The author has contributed to research in topics: Notch signaling pathway & Neural stem cell. The author has an hindex of 25, co-authored 67 publications receiving 4859 citations. Previous affiliations of Keejung Yoon include University of California, San Francisco & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Mats Hellström,Li-Kun Phng,Jennifer J. Hofmann,Elisabet Wallgard,Leigh Coultas,Per Lindblom,Per Lindblom,Jackelyn A. Alva,Ann Katrin Nilsson,Linda Karlsson,Nicholas Gaiano,Keejung Yoon,Janet Rossant,M. Luisa Iruela-Arispe,Mattias Kalén,Holger Gerhardt,Christer Betsholtz +16 more
TL;DR: Evidence is presented that delta-like 4 (Dll4)–Notch1 signalling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina, and modulators of Dll4 or Notch signalling, such as γ-secretase inhibitors developed for Alzheimer's disease, might find usage as pharmacological regulators of angiogenesis.
Journal ArticleDOI
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
Andrew W. Duncan,Frederique M. Rattis,Leah N. DiMascio,Kendra L. Congdon,Gregory Pazianos,Chen Zhao,Keejung Yoon,J. Michael Cook,Karl Willert,Nicholas Gaiano,Tannishtha Reya +10 more
TL;DR: It is shown that the molecular regulation of two critical elements of self-renewal, inhibition of differentiation and induction of proliferation, can be uncoupled, and Notch signaling is identified as a key factor in inhibiting differentiation.
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Notch signaling in the mammalian central nervous system: insights from mouse mutants
Keejung Yoon,Nicholas Gaiano +1 more
TL;DR: The role of Notch in the mammalian CNS is reviewed by focusing specifically on mutations generated in mice, which have provided critical insight into Notch function in the CNS and led to the identification of promising new directions that are likely to generate important discoveries in the future.
Journal ArticleDOI
Differential Notch signalling distinguishes neural stem cells from intermediate progenitors
TL;DR: This study suggests that the use or blockade of the CBF1 cascade downstream of Notch is a general feature distinguishing stem cells from more limited progenitors in a variety of tissues.
Journal ArticleDOI
Fibroblast Growth Factor Receptor Signaling Promotes Radial Glial Identity and Interacts with Notch1 Signaling in Telencephalic Progenitors
Keejung Yoon,Susana Vaz Nery,Michael Rutlin,Freddy Radtke,Gord Fishell,Nicholas Gaiano,Nicholas Gaiano +6 more
TL;DR: This study suggests that telencephalic progenitors with radial glial morphology are maintained by interactions between the Notch and FGF pathways, and that the mechanisms by which FGF signaling promotes radial glia character in vivo and progenitor proliferation in vitro can be uncoupled.