T
Tannishtha Reya
Researcher at University of California, San Diego
Publications - 85
Citations - 25965
Tannishtha Reya is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 42, co-authored 80 publications receiving 23891 citations. Previous affiliations of Tannishtha Reya include University of California, Los Angeles & University of Pennsylvania.
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Journal ArticleDOI
Stem cells, cancer, and cancer stem cells
TL;DR: Stem cell biology has come of age: Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
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Wnt signalling in stem cells and cancer
Tannishtha Reya,Hans Clevers +1 more
TL;DR: Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.
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Wnt proteins are lipid-modified and can act as stem cell growth factors
Karl Willert,Jeffrey Brown,Esther Danenberg,Andrew W. Duncan,Irving L. Weissman,Tannishtha Reya,John R. Yates,Roel Nusse +7 more
TL;DR: This work isolated active Wnt molecules, including the product of the mouse Wnt3a gene, and found the proteins to be palmitoylated on a conserved cysteine, indicating that the lipid is important for signalling.
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A role for Wnt signalling in self-renewal of haematopoietic stem cells
Tannishtha Reya,Andrew W. Duncan,Laurie Ailles,Jos Domen,David C. Scherer,Karl Willert,Lindsay Hintz,Roel Nusse,Irving L. Weissman +8 more
TL;DR: It is concluded that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and insight is provided into a potential molecular hierarchy of regulation of HSC development.
Journal ArticleDOI
Glucose feeds the TCA cycle via circulating lactate.
Sheng Hui,Jonathan M. Ghergurovich,Raphael J. Morscher,Cholsoon Jang,Xin Teng,Wenyun Lu,Lourdes A Esparza,Tannishtha Reya,Le Zhan,Jessie Yanxiang Guo,Eileen White,Joshua D. Rabinowitz,Joshua D. Rabinowitz +12 more
TL;DR: It is found that lactate can be a primary source of carbon for the TCA cycle and thus of energy, and during the fasted state, the contribution of glucose to tissue TCA metabolism is primarily indirect (via circulating lactate) in all tissues except the brain.