K
Kei Tobiume
Researcher at Tokyo Medical and Dental University
Publications - 11
Citations - 5915
Kei Tobiume is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: ASK1 & MAP kinase kinase kinase. The author has an hindex of 8, co-authored 9 publications receiving 5654 citations. Previous affiliations of Kei Tobiume include Japanese Foundation for Cancer Research.
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Chemical inhibition of LSD1 leads to epithelial to mesenchymal transition in vitro of an oral squamous cell carcinoma OM-1 cell line via release from LSD1-dependent suppression of ZEB1.
Naoya Yamakado,Satoshi Okuda,Kei Tobiume,Ryo Uetsuki,Shigehiro Ono,Kuniko Mizuta,Takayuki Nakagawa,Tomonao Aikawa +7 more
TL;DR: In this paper , an adverse effect against cancer therapeutics, which was EMT induction in vitro by the chemical LSD1 inhibitor, was reported, and an additional EMT-TF Snail-dependent partial EMT phenotype in OM-1 progressed to complete EMT in conjunction with LSD 1 inhibitor-dependent ZEB1 induction.