Keiichiro Honma

TL;DR: The study extended the analysis to other subsets of non-Hodgkin lymphomas and found that A20 is frequently deleted in mantle cell lymphoma and diffuse large B-cell lymphoma, raising the possibility that inactivation of A20 may be involved in lymphomagenesis.

TL;DR: Oligo-array comparative genomic hybridization and gene-expression profiling of natural killer (NK)-cell neoplasms were used in an effort to delineate the molecular pathogenesis involved and identified two 6q21 regions that were most frequently deleted.

TL;DR: It is suggested that TNFAIP3 may act as a tumor suppressor gene in ocular adnexal marginal zone B cell lymphoma and correlation between genomic loss and expression level was found only for TNFAip3, demonstrating that TN FAIP3 is a target gene of 6q deletion in ophthalmological lymphoma.

TL;DR: The array CGH profile of ocular MZ BCL is distinct from those of pulmonary and nodal MZBCL, and deletion of chromosome band 6q23.3 in ocular ZBCL is a novel finding and may constitute a crucial genetic alteration in the pathogenesis of ophthalmology.

TL;DR: The importance of genetic alterations other than chromosome translocation has been recognized since the introduction of array comparative genomic hybridization (array CGH) analyses as mentioned in this paper, which indicate that multiple genetic pathways leading to the development of lymphomas may exist and hence result in the variable clinicopathological features observed.