K
Koichi Ohshima
Researcher at Kurume University
Publications - 573
Citations - 18260
Koichi Ohshima is an academic researcher from Kurume University. The author has contributed to research in topics: Lymphoma & Diffuse large B-cell lymphoma. The author has an hindex of 63, co-authored 539 publications receiving 16037 citations. Previous affiliations of Koichi Ohshima include University of Miyazaki & St. Vincent's Health System.
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Journal ArticleDOI
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.
Fumihiko Ishikawa,Shuro Yoshida,Yoriko Saito,Atsushi Hijikata,Hiroshi Kitamura,Satoshi Tanaka,Ryu Nakamura,Toru Tanaka,Hiroko Tomiyama,Noriyuki Saito,Mitsuhiro Fukata,Toshihiro Miyamoto,Bonnie L. Lyons,Koichi Ohshima,Naoyuki Uchida,Shuichi Taniguchi,Osamu Ohara,Koichi Akashi,Koichi Akashi,Mine Harada,Leonard D. Shultz +20 more
TL;DR: A primary human AML xenotransplantation model using newborn nonobese diabetic/severe combined immunodeficient/interleukin (NOD/SCID/IL)2rγnull mice carrying a complete null mutation of the cytokine γc upon the SCID background is developed, demonstrating that LS cells exclusively recapitulate AML and retain self-renewal capacity in vivo.
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Genetic variants of IL-13 signalling and human asthma and atopy
Andrea Heinzmann,X. Q. Mao,Mina Akaiwa,R. T. Kreomer,Peisong Gao,Koichi Ohshima,R. Umeshita,R. Umeshita,Yoshito Abe,Sandra Braun,Tetsuji Yamashita,Mark H. Roberts,Rie Sugimoto,Kazuhiko Arima,Yojiro Arinobu,Bin Yu,S. Kruse,Tadao Enomoto,Y. Dake,M. Kawai,S. Shimazu,S. Sasaki,Chaker N. Adra,M. Kitaichi,Hiroshi Inoue,Kohei Yamauchi,Nobukazu Tomichi,Fumihiko Kurimoto,Naotaka Hamasaki,Julian M. Hopkin,Kenji Izuhara,T. Shirakawa,Klaus A. Deichmann +32 more
TL;DR: Detailed molecular modelling analyses indicate that residue 110 of IL-13, the site of the charge-modifying variants Arg and Gln, is important in the internal constitution of the ligand and crucial in ligand-receptor interaction, likely to be important promoters of human asthma.
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Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders Constitute a Distinct Clinicopathologic Group: A Study of 96 Patients
Takashi Oyama,Kazuhito Yamamoto,Naoko Asano,Aya Oshiro,Ritsuro Suzuki,Yoshitoyo Kagami,Yasuo Morishima,Kengo Takeuchi,Toshiyuki Izumo,Shigeo Mori,Koichi Ohshima,Junji Suzumiya,Naoya Nakamura,Masafumi Abe,Koichi Ichimura,Yumiko Sato,Tadashi Yoshino,Tomoki Naoe,Yoshie Shimoyama,Yoshikazu Kamiya,Tomohiro Kinoshita,Shigeo Nakamura +21 more
TL;DR: Findings suggest that age-related EBV+ B-cell LPDs constitute a distinct group, and innovative therapeutic strategies such as EBV-targeted T-cell therapy should be developed for this uncommon disease.
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Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma.
Junichi Kiyasu,Junichi Kiyasu,Hiroaki Miyoshi,Akie Hirata,Fumiko Arakawa,Ayako Ichikawa,Daisuke Niino,Yasuo Sugita,Yuji Yufu,Ilseung Choi,Yasunobu Abe,Naokuni Uike,Koji Nagafuji,Takashi Okamura,Koichi Akashi,Ryoichi Takayanagi,Motoaki Shiratsuchi,Koichi Ohshima +17 more
TL;DR: Patients with PD-L1(+) DLBCL had inferior overall survival (OS) compared with that in patients withPD-L 1(-)DLBCL (P = .0009); in contrast, there was no significant difference in OS between mPD- L1(+) and mPD/PAX5(+), and the expression of PD- l1 maintained prognostic value for OS in multivariate analysis.
Journal ArticleDOI
Senile EBV+ B-cell lymphoproliferative disorders: a clinicopathologic study of 22 patients.
Takashi Oyama,Koichi Ichimura,Ritsuro Suzuki,Junji Suzumiya,Koichi Ohshima,Yasushi Yatabe,Takio Yokoi,Masaru Kojima,Yoshikazu Kamiya,Hirofumi Taji,Yoshitoyo Kagami,Michinori Ogura,Hidehiko Saito,Yasuo Morishima,Shigeo Nakamura +14 more
TL;DR: It is suggested that Epstein-Barr virus-associated LPD without immunodeficiency mainly occurs in elderly patients, and there was a significant difference in prognosis between the group with polymorphic LPDs and the one with large cell lymphomas.