K
Kennosuke Karube
Researcher at University of the Ryukyus
Publications - 109
Citations - 2644
Kennosuke Karube is an academic researcher from University of the Ryukyus. The author has contributed to research in topics: Lymphoma & Medicine. The author has an hindex of 23, co-authored 93 publications receiving 2280 citations. Previous affiliations of Kennosuke Karube include University of Barcelona & Kurume University.
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Journal ArticleDOI
Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
Kotaro Shide,Haruko Shimoda,Takashi Kumano,Kennosuke Karube,Takuro Kameda,Katsuto Takenaka,Seido Oku,Hiroo Abe,Keiko Katayose,Youko Kubuki,Kazunori Kusumoto,Satoru Hasuike,Yoshihiro Tahara,Kenji Nagata,Tadashi Matsuda,Kouichi Ohshima,Mine Harada,Kazuya Shimoda +17 more
TL;DR: It is concluded that in vivo expression of JAK2 V617F results in ET-, PMF- and PV-like disease.
Journal ArticleDOI
Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses
Kennosuke Karube,Masao Nakagawa,Shinobu Tsuzuki,Ichiro Takeuchi,Keiichiro Honma,Yasuhiro Nakashima,Norio Shimizu,Young Hyeh Ko,Yasuo Morishima,Koichi Ohshima,Shigeo Nakamura,Masao Seto +11 more
TL;DR: Oligo-array comparative genomic hybridization and gene-expression profiling of natural killer (NK)-cell neoplasms were used in an effort to delineate the molecular pathogenesis involved and identified two 6q21 regions that were most frequently deleted.
Journal ArticleDOI
Synergistic action of the microRNA-17 polycistron and Myc in aggressive cancer development.
TL;DR: The results suggest that miR is stably upregulated in the presence of constitutive expression of Myc, and that the deregulation of miR and Myc synergistically contribute to aggressive cancer development, probably by repressing tumor suppressor genes.
Journal ArticleDOI
Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma.
Aya Oshiro,Hiroyuki Tagawa,Koichi Ohshima,Kennosuke Karube,Naokuni Uike,Yukie Tashiro,Atae Utsunomiya,Masato Masuda,Nobuyuki Takasu,Shigeo Nakamura,Yasuo Morishima,Masao Seto +11 more
TL;DR: It is suggested that acute and lymphoma types are genomically distinct subtypes, and thus may develop tumors via distinct genetic pathways.
Journal ArticleDOI
Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets.
Kennosuke Karube,Kennosuke Karube,Anna Enjuanes,Ivan Dlouhy,Pedro Jares,David Martín-García,Ferran Nadeu,Gonzalo R. Ordóñez,Jordina Rovira,Guillem Clot,Cristina Royo,Alfons Navarro,Blanca Gonzalez-Farre,A Vaghefi,Giancarlo Castellano,Carlota Rubio-Perez,David Tamborero,Javier Briones,Antonio Salar,Juan-Manuel Sancho,Santiago Mercadal,Eva González-Barca,Lourdes Escoda,Hiroaki Miyoshi,Koichi Ohshima,Kohta Miyawaki,Koji Kato,Koichi Akashi,Ana Mozos,Luis Colomo,Luis Colomo,Miguel Alcoceba,Alexandra Valera,Anna Carrió,Dolors Costa,Nuria Lopez-Bigas,Nuria Lopez-Bigas,Roland Schmitz,L. M. Staudt,Itziar Salaverria,Armando López-Guillermo,Elias Campo +41 more
TL;DR: A gene expression profiling analysis showed that tumors with NOTCH pathway mutations had a significant modulation of downstream target genes, emphasizing the relevance of this pathway in DLBCL.