K
Keiko Kawauchi
Researcher at Konan University
Publications - 52
Citations - 1922
Keiko Kawauchi is an academic researcher from Konan University. The author has contributed to research in topics: Actin cytoskeleton & Cancer cell. The author has an hindex of 18, co-authored 47 publications receiving 1635 citations. Previous affiliations of Keiko Kawauchi include University of Hyogo & Nippon Medical School.
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Journal ArticleDOI
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.
TL;DR: The results suggest that a positive-feedback loop exists, whereby glycolysis drives IKK–NF-κB activation, and that hyperactivation of this loop by loss of p53 is important in oncogene-induced cell transformation.
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Loss of p53 enhances catalytic activity of IKKβ through O-linked β-N-acetyl glucosamine modification
TL;DR: A novel mechanism for the enhancement of NF-κB activity by loss of p53 is proposed, which evokes positive feedback regulation from enhanced glucose metabolism to IKK in oncogenesis.
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Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.
Yoshinori Abe,Eri Oda-Sato,Kei Tobiume,Keiko Kawauchi,Yoichi Taya,Koji Okamoto,Moshe Oren,Nobuyuki Tanaka +7 more
TL;DR: It is found that accumulation of p53 is inhibited by Hh signaling in several human cancer cell lines, suggesting that the Hh pathway may be a powerful accelerator of oncogenesis by activating cell proliferation and inhibiting the p53-mediated anti-cancer barrier induced by oncogenic stress.
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A possible immunosuppressant, cycloprodigiosin hydrochloride, obtained from Pseudoalteromonas denitrificans
Keiko Kawauchi,Kiriko Shibutani,Hitoshi Yagisawa,Hideaki Kamata,Shin'ichi Nakatsuji,Hiroyuki Anzai,Yoshindo Yokoyama,Yoshinari Ikegami,Yoshinori Moriyama,Hajime Hirata +9 more
TL;DR: Crystalline cPrG.HCl selectively uncouples H+ translocation from the ATPase reaction rather than acting as a non-specific ionophore, which raises the possibility of its therapeutic use as an immunosuppressant.
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Interleukin 6 Enhances Glycolysis through Expression of the Glycolytic Enzymes Hexokinase 2 and 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase-3
Masaru Ando,Ikuno Uehara,Kayo Kogure,Yumi Asano,Wataru Nakajima,Yoshinori Abe,Keiko Kawauchi,Nobuyuki Tanaka +7 more
TL;DR: It is found that the proinflammatory cytokine interleukin (IL)-6 enhanced glycolysis in mouse embryonic fibroblasts and human cell lines and STAT3 activated by IL-6 enhanced the expression of the gly colytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3).