Keiko Ono

TL;DR: Two different models of overt heart failure may be useful as models of isolated diastolic heart failure and systolicheart failure based on the same hypertensive heart disease, respectively, and may contribute to discrimination of the mechanisms of the development of the two different phenotypes of heart failure.

TL;DR: Development of pressure overload LV hypertrophy is associated with evolving changes in MFVP from normal to relaxation abnormality pattern and, in turn, to pseudonormalized to restrictive pattern.

TL;DR: Calcineurin inhibition, if started from the initial stage of pressure overload, attenuated the development of LV hypertrophy without any effect on LV fibrosis and prevented the transition to heart failure.

TL;DR: The transition to isolated diastolic heart failure in hypertrophied hearts was associated with preserved gene expression of the renin-angiotensin system and 'overdrive' of gene expressionOf the ET system, suggesting that BNP gene expression is likely to be activated by the progression of diastolics failure rather than by LV hypertrophy alone.

TL;DR: In this article, the authors attempted to establish echocardiographic measurements of left ventricular (LV) mass and LV systolic and diastolic function, particularly in rats with hypertensive heart.