H
Hiroshi Takeda
Researcher at Osaka University
Publications - 72
Citations - 3464
Hiroshi Takeda is an academic researcher from Osaka University. The author has contributed to research in topics: Heart failure & Health care. The author has an hindex of 25, co-authored 72 publications receiving 3334 citations.
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Journal ArticleDOI
Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure
Katsuji Imai,Hideyuki Sato,Masatsugu Hori,Hideo Kusuoka,Hitoshi Ozaki,Hiroshi Yokoyama,Hiroshi Takeda,Michitoshi Inoue,Takenobu Kamada +8 more
TL;DR: The results indicate that T30 is mediated primarily by vagal reactivation, independent of sympathetic withdrawal, and is significantly smaller in athletes and significantly larger in patients with chronic heart failure than that in respective age-matched normal control subjects.
Journal ArticleDOI
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy
Masanori Asakura,Masafumi Kitakaze,Seiji Takashima,Yulin Liao,Fuminobu Ishikura,Tsuyoshi Yoshinaka,Hiroshi Ohmoto,Koichi Node,Kohichiro Yoshino,Hiroshi Ishiguro,Hiroshi Asanuma,Shoji Sanada,Yasushi Matsumura,Hiroshi Takeda,Shintaro Beppu,Michihiko Tada,Masatsugu Hori,Shigeki Higashiyama +17 more
TL;DR: It is suggested that inhibition of HB-EGF shedding could be a potent therapeutic strategy for cardiac hypertrophy and that dominant-negative expression of ADAM12 abrogated this signaling.
Journal ArticleDOI
Prognostic significance of atrial fibrillation/atrial flutter in patients with acute myocardial infarction treated with percutaneous coronary intervention.
Kunihiro Kinjo,Hiroshi Sato,Hideyuki Sato,Yozo Ohnishi,Eiji Hishida,Daisaku Nakatani,Hiroya Mizuno,Masatake Fukunami,Yukihiro Koretsune,Hiroshi Takeda,Masatsugu Hori +10 more
TL;DR: AF is a common complication in patients with AMI who are treated with PCI and independently influences 1-year mortality and Multivariate Cox regression analysis revealed that AF was an independent predictor of 1- year mortality but was not a predictor of in-hospital mortality.
Journal ArticleDOI
Pravastatin restored the infarct size-limiting effect of ischemic preconditioning blunted by hypercholesterolemia in the rabbit model of myocardial infarction.
Yasunori Ueda,Masafumi Kitakaze,Kazuo Komamura,Tetsuo Minamino,Hiroshi Asanuma,Hideyuki Sato,Tsunehiko Kuzuya,Hiroshi Takeda,Masatsugu Hori +8 more
TL;DR: Pravastatin, at the dose serum cholesterol was not normalized, restored the IS-limiting effect of IP and IP-induced ecto-5'-nucleotidase activation, which were both blunted by hypercholesterolemia.
Journal ArticleDOI
Identification of 187 single nucleotide polymorphisms (SNPs) among 41 candidate genes for ischemic heart disease in the Japanese population.
Yozo Ohnishi,Toshihiro Tanaka,Ryo Yamada,K. Suematsu,M. Minami,K. Fujii,N. Hoki,Ken Kodama,S. Nagata,T. Hayashi,N. Kinoshita,Hiroshi Sato,Tsunehiko Kuzuya,Hiroshi Takeda,Masatsugu Hori,Yusuke Nakamura +15 more
TL;DR: Data support the hypothesis that some SNPs are specific to particular ethnic groups, as well as the allelic frequencies of some of the polymorphisms, which were significantly different from those reported in European populations.