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Masatsugu Hori
Researcher at Osaka University
Publications - 880
Citations - 50449
Masatsugu Hori is an academic researcher from Osaka University. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 113, co-authored 874 publications receiving 48028 citations. Previous affiliations of Masatsugu Hori include Kagoshima University & Kwansei Gakuin University.
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Journal ArticleDOI
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.
Atsuko Nakai,Osamu Yamaguchi,Toshihiro Takeda,Yoshiharu Higuchi,Shungo Hikoso,Masayuki Taniike,Shigemiki Omiya,Isamu Mizote,Yasushi Matsumura,Michio Asahi,Kazuhiko Nishida,Masatsugu Hori,Noboru Mizushima,Noboru Mizushima,Kinya Otsu +14 more
TL;DR: Results indicate that constitutive autophagy in the heart under baseline conditions is a homeostatic mechanism for maintaining cardiomyocyte size and global cardiac structure and function, and that upregulation of autophagic in failing hearts is an adaptive response for protecting cells from hemodynamic stress.
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Clinical Implications of the ‘No Reflow’ Phenomenon A Predictor of Complications and Left Ventricular Remodeling in Reperfused Anterior Wall Myocardial Infarction
Hiroshi Ito,Atsushi Maruyama,Katsuomi Iwakura,Shin Takiuchi,Tohru Masuyama,Masatsugu Hori,Yorihiko Higashino,Kenshi Fujii,Takazo Minamino +8 more
TL;DR: The substantial size of the MCE no reflow phenomenon at coronary reflow conveys useful information about an outcome of coronary intervention and left ventricular remodeling in individual patients with anterior wall AMI, although these are suggestive results in a limited number of patients.
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Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure
Katsuji Imai,Hideyuki Sato,Masatsugu Hori,Hideo Kusuoka,Hitoshi Ozaki,Hiroshi Yokoyama,Hiroshi Takeda,Michitoshi Inoue,Takenobu Kamada +8 more
TL;DR: The results indicate that T30 is mediated primarily by vagal reactivation, independent of sympathetic withdrawal, and is significantly smaller in athletes and significantly larger in patients with chronic heart failure than that in respective age-matched normal control subjects.
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Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction.
Kouichi Ozaki,Yozo Ohnishi,Aritoshi Iida,Akihiko Sekine,Ryo Yamada,Tatsuhiko Tsunoda,Hiroshi Sato,Hideyuki Sato,Masatsugu Hori,Yusuke Nakamura,Toshihiro Tanaka +10 more
TL;DR: Results indicate that variants in the LTA are risk factors for myocardial infraction and implicate LTA in the pathogenesis of the disorder.
Journal ArticleDOI
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy
Masanori Asakura,Masafumi Kitakaze,Seiji Takashima,Yulin Liao,Fuminobu Ishikura,Tsuyoshi Yoshinaka,Hiroshi Ohmoto,Koichi Node,Kohichiro Yoshino,Hiroshi Ishiguro,Hiroshi Asanuma,Shoji Sanada,Yasushi Matsumura,Hiroshi Takeda,Shintaro Beppu,Michihiko Tada,Masatsugu Hori,Shigeki Higashiyama +17 more
TL;DR: It is suggested that inhibition of HB-EGF shedding could be a potent therapeutic strategy for cardiac hypertrophy and that dominant-negative expression of ADAM12 abrogated this signaling.