K
Keisaku Sato
Researcher at Indiana University – Purdue University Indianapolis
Publications - 30
Citations - 808
Keisaku Sato is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 17 publications receiving 488 citations. Previous affiliations of Keisaku Sato include Texas A&M Health Science Center & Texas A&M Health Science Center College of Medicine.
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Journal ArticleDOI
Ductular reaction in liver diseases: pathological mechanisms and translational significances
Keisaku Sato,Keisaku Sato,Keisaku Sato,Marco Marzioni,Fanyin Meng,Fanyin Meng,Heather Francis,Heather Francis,Heather Francis,Shannon Glaser,Shannon Glaser,Shannon Glaser,Gianfranco Alpini,Gianfranco Alpini,Gianfranco Alpini +14 more
TL;DR: Although further studies are needed to elucidate detailed mechanisms and the functional roles in liver diseases, DR can be a therapeutic target to inhibit liver fibrosis and to promote liver regeneration.
Journal ArticleDOI
Exosomes in liver pathology
TL;DR: Recent findings on the role of extracellular vesicles in liver diseases and their diagnostic and therapeutic potential are summarized, mainly focusing on exosomes but also includes microvesicle in liver pathology.
Journal ArticleDOI
Pathogenesis of Kupffer Cells in Cholestatic Liver Injury
Keisaku Sato,Chad Hall,Shannon Glaser,Shannon Glaser,Shannon Glaser,Heather Francis,Heather Francis,Heather Francis,Fanyin Meng,Fanyin Meng,Fanyin Meng,Gianfranco Alpini,Gianfranco Alpini,Gianfranco Alpini +13 more
TL;DR: It is suggested that Kupffer cells orchestrate with other liver cells to relay inflammatory signals and to maintain liver homeostasis during BDL-induced liver injury, followed by hepatic inflammation and fibrosis.
Journal ArticleDOI
Mechanisms of cholangiocyte responses to injury.
Keisaku Sato,Fanyin Meng,Thao Giang,Shannon Glaser,Gianfranco Alpini,Gianfranco Alpini,Gianfranco Alpini +6 more
TL;DR: Current studies of biliary response and cholangiocyte proliferation during cholestatic liver injury with particular emphasis on the secretin/secretin receptor axis are summarized.
Journal ArticleDOI
The let-7/lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury
Kelly McDaniel,Kelly McDaniel,Li Huang,Keisaku Sato,Nan Wu,Tami Annable,Tami Annable,Tianhao Zhou,Tianhao Zhou,Sugeily Ramos-Lorenzo,Ying Wan,Ying Wan,Qiaobing Huang,Heather Francis,Heather Francis,Shannon Glaser,Shannon Glaser,Hidekazu Tsukamoto,Gianfranco Alpini,Gianfranco Alpini,Fanyin Meng,Fanyin Meng +21 more
TL;DR: The identification of the let-7/Lin28 axis as an important regulator of HSC activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis and novel therapeutic approaches for human alcoholic liver diseases.