K
Keisuke Ono
Researcher at Tokyo University of Science
Publications - 21
Citations - 404
Keisuke Ono is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Kinetic resolution & Catalysis. The author has an hindex of 9, co-authored 21 publications receiving 383 citations. Previous affiliations of Keisuke Ono include University of Tokyo.
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Kinetic Resolution of Racemic α-Arylalkanoic Acids with Achiral Alcohols via the Asymmetric Esterification Using Carboxylic Anhydrides and Acyl-Transfer Catalysts
TL;DR: This protocol was successfully applied to the production of nonracemic nonsteroidal anti-inflammatory drugs from racemic compounds utilizing the transacylation process to generate the mixed anHydrides from the acid components with the suitable carboxylic anhydrides.
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Kinetic resolution of the racemic 2-hydroxyalkanoates using the enantioselective mixed-anhydride method with pivalic anhydride and a chiral acyl-transfer catalyst.
TL;DR: This protocol directly provides the desired chiral 2-hydroxyalkanoate derivatives from achiral diarylacetic acid and racemic secondary alcohols that do not include the sec-phenethyl alcohol moiety by using the transacylation process to generate the mixed anHydrides from the acid components with bulky carboxylic anhydrides under the influence of the chiral acyl-transfer catalyst.
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Kinetic Resolution of Racemic 2-Hydroxy-γ-butyrolactones by Asymmetric Esterification Using Diphenylacetic Acid with Pivalic Anhydride and a Chiral Acyl-Transfer Catalyst
TL;DR: The reaction mechanism to afford high enantioselectivity using theoretical calculations is disclosed and the substituent effects at the C-3 positions in 2-hydroxylactones are expounded.
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2,2-disubstituted propionic anhydrides : effective coupling reagents for the kinetic resolution of secondary benzylic alcohols using btm
TL;DR: In this paper, a variety of optically active benzylic alcohols possessing aliphatic substituents at the C-1 position are produced by the kinetic resolution of racemic secondary alcohols using free carboxylic acids with 2,2-disubstituted propionic anhydrides and (+)-benzotetramisole (BTM).
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Kinetic Resolution of Racemic 1-Heteroarylalkanols by Asymmetric Esterification Using Diphenylacetic Acid with Pivalic Anhydride and a Chiral Acyl-transfer Catalyst
TL;DR: A variety of optically active 1-heteroarylalkanols and their esters, which include heteroaromatic moieties, such as 2-furyl, 2-thienyl, 3-THienyl and 2-THI, were discussed in this paper.