Keith E. Tansey

TL;DR: The findings show that reactive astrocytes provide essential activities that protect tissue and preserve function after mild or moderate SCI, and suggest that identifying ways to preserve reactive astracytes, to augment their protective functions, or both, may lead to novel approaches to reducing secondary tissue degeneration and improving functional outcome after SCI.

TL;DR: A role for TNF is demonstrated in vitro and in vivo in two models of PD, and the possibility that delaying the progressive degeneration of the nigrostriatal pathway in humans is therapeutically feasible with agents capable of blocking solTNF in early stages of PD is raised.

TL;DR: Intensive task-specific rehabilitative training, such as robotic BWSTT, can promote supraspinal plasticity in the motor centers known to be involved in locomotion and improvement in over-ground locomotion is accompanied by an increased activation of the cerebellum.

TL;DR: An “age-at-injury”-related difference that may influence training effectiveness is demonstrated, that successful treadmill step training can alter electrophysiological parameters in the transected spinal cord, and that activation of different pathways may prevent functional improvement.

TL;DR: Preliminary results suggest that tSCS, similar to epidurally delivered stimulation, may be used for spasticity control, without negatively impacting residual motor control in incomplete SCI.