K
Kelly A. Ruhn
Researcher at University of Texas Southwestern Medical Center
Publications - 34
Citations - 5470
Kelly A. Ruhn is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Neurodegeneration & Substantia nigra. The author has an hindex of 22, co-authored 33 publications receiving 4556 citations.
Papers
More filters
Journal ArticleDOI
The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
Shipra Vaishnava,Miwako Yamamoto,Kari M. Severson,Kelly A. Ruhn,Xiaofei Yu,Omry Koren,Ruth E. Ley,Edward K. Wakeland,Lora V. Hooper +8 more
TL;DR: It is shown that RegIIIγ, a secreted antibacterial lectin, is essential for maintaining a ~50-micrometer zone that physically separates the microbiota from the small intestinal epithelial surface.
Supporting Online Material for The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
Shipra Vaishnava,Miwako Yamamoto,Kari M. Severson,Kelly A. Ruhn,Xiaofei Yu,Omry Koren,Ruth E. Ley,Edward K. Wakeland,Lora V. Hooper +8 more
Journal ArticleDOI
Th17 cell differentiation is regulated by the circadian clock
Xiaofei Yu,Darcy Rollins,Kelly A. Ruhn,Jeremy J. Stubblefield,Carla B. Green,Masaki Kashiwada,Masaki Kashiwada,Paul B. Rothman,Joseph S. Takahashi,Lora V. Hooper +9 more
TL;DR: It is shown that the molecular circadian clock directly regulates the differentiation of TH17 cells in the intestine, which suggest that both nutrition and light are important environmental factors that directly regulate the immune response.
Journal ArticleDOI
Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease.
Melissa K. McCoy,Terina N Martinez,Kelly A. Ruhn,David E. Szymkowski,Christine G. Smith,B. R. Botterman,Keith E. Tansey,Malú G. Tansey +7 more
TL;DR: A role for TNF is demonstrated in vitro and in vivo in two models of PD, and the possibility that delaying the progressive degeneration of the nigrostriatal pathway in humans is therapeutically feasible with agents capable of blocking solTNF in early stages of PD is raised.
Journal ArticleDOI
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
TL;DR: Mechanistic insight is provided into how the intestinal microbiota regulates body composition and NFIL3 is established as an essential molecular link among the microbiota, the circadian clock, and host metabolism.