K
Keith Mccullagh
Researcher at University of Copenhagen
Publications - 3
Citations - 698
Keith Mccullagh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Gene silencing & Locked nucleic acid. The author has an hindex of 1, co-authored 3 publications receiving 668 citations.
Papers
More filters
Journal ArticleDOI
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver
Joacim Elmén,Morten Lindow,Asli Silahtaroglu,Mads Bak,Mette Christensen,Allan Lind-Thomsen,Maj Hedtjärn,Jens Bo Hansen,Henrik Hansen,Ellen Marie Straarup,Keith Mccullagh,Phil Kearney,Sakari Kauppinen +12 more
TL;DR: The data suggest that miRNA antagonists comprised of LNA are valuable tools for identifying miRNA targets in vivo and for studying the biological role of miRNAs and miRNA-associated gene-regulatory networks in a physiological context.
Patent
Method for the treatment of cancer
TL;DR: In this paper, a combination therapy for the treatment of cancer using LNA oligomers targeting Bcl-2 in conjunction with CD-20 inhibitors, such as Rituximab, or a CD20 antibody is selected from the group consisting of Ofatumumab (2F2), 11B8, 7D8, 2C6, Veltuzumab, AME-133v Ibritumomab Tiuxetan, Tositummab, TRU-015, 2H7.vl6, Ocrelizumab
Patent
Composes antagonistes d'arn permettant la modulation de fabp4/ap2
TL;DR: The authors concerne des oligonucleotides diriges contre le gene FABP4, utiles dans la modulation de l'expression of the proteine FABB4.