S
Sakari Kauppinen
Researcher at Aalborg University – Copenhagen
Publications - 123
Citations - 23479
Sakari Kauppinen is an academic researcher from Aalborg University – Copenhagen. The author has contributed to research in topics: microRNA & Gene silencing. The author has an hindex of 62, co-authored 114 publications receiving 21917 citations. Previous affiliations of Sakari Kauppinen include Dartmouth College & Aalborg University.
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Journal ArticleDOI
Treatment of HCV Infection by Targeting MicroRNA
Harry L.A. Janssen,Hendrik W. Reesink,Eric Lawitz,Stefan Zeuzem,Maribel Rodriguez-Torres,Keyur Patel,Adriaan J. van der Meer,Amy K. Patick,Alice Chen,Yi Zhou,Robert Persson,Barney D King,Sakari Kauppinen,Arthur A. Levin,Michael R. Hodges +14 more
TL;DR: The use of miravirsen in patients with chronic HCV genotype 1 infection showed prolonged dose-dependent reductions in HCV RNA levels without evidence of viral resistance.
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Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
Robert E. Lanford,Elisabeth S. Hildebrandt-Eriksen,Andreas Petri,Robert Persson,Morten Lindow,Martin E. Munk,Sakari Kauppinen,Sakari Kauppinen,Henrik Ørum +8 more
TL;DR: Treatment of chronically infected chimpanzees with a locked nucleic acid (LNA)–modified oligonucleotide (SPC3649) complementary to miR-122 leads to long-lasting suppression of HCV viremia, with no evidence of viral resistance or side effects in the treated animals.
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LNA-mediated microRNA silencing in non-human primates
Joacim Elmén,Morten Lindow,Sylvia Schütz,Matthew Lawrence,Andreas Petri,Susanna Obad,Marie Lindholm,Maj Hedtjärn,Henrik Frydenlund Hansen,Urs V. Berger,Steven R. Gullans,Phil Kearney,Peter Sarnow,Ellen Marie Straarup,Sakari Kauppinen,Sakari Kauppinen +15 more
TL;DR: The utility of systemically administered LNA-antimiRs in exploring miRNA function in rodents and primates is demonstrated, and the potential of these compounds as a new class of therapeutics for disease-associated miRNAs is supported.
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MicroRNA Expression in Zebrafish Embryonic Development
Erno Wienholds,Wigard P. Kloosterman,Eric A. Miska,Ezequiel Alvarez-Saavedra,Eugene Berezikov,Ewart de Bruijn,H. Robert Horvitz,Sakari Kauppinen,Ronald H.A. Plasterk +8 more
TL;DR: Most miRNAs were expressed in a highly tissue-specific manner during segmentation and later stages, but not early in development, which suggests that their role is not in tissue fate establishment but in differentiation or maintenance of tissue identity.
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Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.
Sébastien S. Hébert,Katrien Horré,Laura Nicolaï,Aikaterini S. Papadopoulou,Wim Mandemakers,Asli Silahtaroglu,Sakari Kauppinen,Sakari Kauppinen,André Delacourte,Bart De Strooper +9 more
TL;DR: It is shown here that miR-29a, -29b-1, and -9 can regulate Bace1 expression in vitro and proposed that loss of specific miRNAs can contribute to increased BACE1 and Aβ levels in sporadic AD.