J
Joacim Elmén
Researcher at Santaris Pharma a/s
Publications - 14
Citations - 3773
Joacim Elmén is an academic researcher from Santaris Pharma a/s. The author has contributed to research in topics: Gene silencing & Locked nucleic acid. The author has an hindex of 10, co-authored 14 publications receiving 3594 citations. Previous affiliations of Joacim Elmén include Novo Nordisk.
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Journal ArticleDOI
LNA-mediated microRNA silencing in non-human primates
Joacim Elmén,Morten Lindow,Sylvia Schütz,Matthew Lawrence,Andreas Petri,Susanna Obad,Marie Lindholm,Maj Hedtjärn,Henrik Frydenlund Hansen,Urs V. Berger,Steven R. Gullans,Phil Kearney,Peter Sarnow,Ellen Marie Straarup,Sakari Kauppinen,Sakari Kauppinen +15 more
TL;DR: The utility of systemically administered LNA-antimiRs in exploring miRNA function in rodents and primates is demonstrated, and the potential of these compounds as a new class of therapeutics for disease-associated miRNAs is supported.
Journal ArticleDOI
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver
Joacim Elmén,Morten Lindow,Asli Silahtaroglu,Mads Bak,Mette Christensen,Allan Lind-Thomsen,Maj Hedtjärn,Jens Bo Hansen,Henrik Hansen,Ellen Marie Straarup,Keith Mccullagh,Phil Kearney,Sakari Kauppinen +12 more
TL;DR: The data suggest that miRNA antagonists comprised of LNA are valuable tools for identifying miRNA targets in vivo and for studying the biological role of miRNAs and miRNA-associated gene-regulatory networks in a physiological context.
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MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction
Jannet Kocerha,Mohammad Ali Faghihi,Miguel A. Lopez-Toledano,Jia Huang,Jia Huang,Amy J. Ramsey,Marc G. Caron,Nicole Salès,David Willoughby,Joacim Elmén,Henrik Frydenlund Hansen,Henrik Ørum,Sakari Kauppinen,Sakari Kauppinen,Paul J. Kenny,Claes Wahlestedt +15 more
TL;DR: In vivo inhibition of miR-219 by specific antimiR in the murine brain significantly modulated behavioral responses associated with disrupted NMDA receptor transmission, and pretreatment with the antipsychotic drugs haloperidol and clozapine prevented dizocilpine-induced effects on miR -219.
Journal ArticleDOI
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
Mirco Castoldi,Maja Vujić Spasić,Sandro Altamura,Joacim Elmén,Morten Lindow,Judit Kiss,Jens Stolte,Richard Sparla,Lorenza A. D'Alessandro,Ursula Klingmüller,Robert E. Fleming,Thomas Longerich,Hermann J. Gröne,Vladimir Benes,Sakari Kauppinen,Sakari Kauppinen,Matthias W. Hentze,Martina U. Muckenthaler +17 more
TL;DR: Inhibition of miR-122 increased the amount of mRNA transcribed by genes that control systemic iron levels, such as hemochromatosis (Hfe), hemojuvelin (Hjv), bone morphogenetic protein receptor type 1A (Bmpr1a), and Hamp and directly targeted the 3′ untranslated region of 2 mRNAs that encode activators of hepcidin expression, Hfe and Hjv.
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The utility of LNA in microRNA-based cancer diagnostics and therapeutics.
TL;DR: LNA is a conformational RNA analoque that binds complementary RNA with unprecedented affinity and specificity that makes LNA well suited for miRNA detection and analysis for cancer diagnostics and recent studies on LNA-mediated silencing of miRNA function in vitro and in vivo support the potential of LNA in therapeutic intervention of cancer-associated miRNAs.