K
Kelli Monteiro da Costa
Researcher at Federal University of Rio de Janeiro
Publications - 28
Citations - 269
Kelli Monteiro da Costa is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 17 publications receiving 148 citations. Previous affiliations of Kelli Monteiro da Costa include Federal Fluminense University.
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Journal ArticleDOI
Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses
Alexandre Morrot,Alexandre Morrot,Leonardo Marques da Fonseca,Eduardo J. Salustiano,Luciana B. Gentile,Luciana Conde,Alessandra A. Filardy,Tatiany N. Franklim,Kelli Monteiro da Costa,Celio Geraldo Freire-de-Lima,Leonardo Freire-de-Lima +10 more
TL;DR: Recent advances regarding the deleterious effect of high concentrations of lactate on the tumor-infiltrating immune cells are discussed, which might characterize an innovative way of understanding the tumors-immune privilege.
Journal ArticleDOI
Inhibition of glycosphingolipid biosynthesis reverts multidrug resistance by differentially modulating ABC transporters in chronic myeloid leukemias.
Eduardo J. Salustiano,Kelli Monteiro da Costa,Leonardo Freire-de-Lima,Lucia Mendonça-Previato,José O. Previato +4 more
TL;DR: Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms, and this work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR haemorrhage.
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Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells.
Leonardo Marques da Fonseca,Lucas Rodrigues Jacques da Silva,Jhenifer Santos dos Reis,Marcos André Rodrigues da Costa Santos,Victoria de Sousa Chaves,Kelli Monteiro da Costa,Julliana de Nazareth Sa-Diniz,Celio Geraldo Freire de Lima,Alexandre Morrot,Alexandre Morrot,Tatiany N. Franklim,Douglas Chaves de Alcântara-Pinto,Marco Edilson Freire de Lima,José O. Previato,Lucia Mendonça-Previato,Leonardo Freire-de-Lima +15 more
TL;DR: Piperine might be further used in therapeutic strategies for metastatic cancer and EMT-related disorders, as well as its ability to inhibit E MT-related events induced by TGF-β1 treatment.
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Theft and Reception of Host Cell's Sialic Acid: Dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like Molecules on Chagas' Disease Immunomodulation.
Leonardo Marques da Fonseca,Kelli Monteiro da Costa,Victoria de Sousa Chaves,Celio Geraldo Freire-de-Lima,Alexandre Morrot,Alexandre Morrot,Lucia Mendonça-Previato,José O. Previato,Leonardo Freire-de-Lima +8 more
TL;DR: The importance of mucin-like glycoproteins and both aTS and iTS for T. cruzi biology is discussed, as well as to present a snapshot of how disturbances in both parasite and host cell sialoglycophenotypes may facilitate the persistence of T.cruzi in the infected mammalian host.
Journal ArticleDOI
Functional Characterization of ABCC Proteins from Trypanosoma cruzi and Their Involvement with Thiol Transport.
Kelli Monteiro da Costa,Raphael C Valente,Eduardo J. Salustiano,Luciana B. Gentile,Leonardo Freire-de-Lima,Lucia Mendonça-Previato,José O. Previato +6 more
TL;DR: The results provide the first description of native ABCC-like activity in T. cruzi epimastigote and trypomastsigote forms, indicating that the study of the biological role for that thiol transporter is crucial to reveal new molecular mechanisms for therapeutic approaches in the Chagas disease.