L
Leonardo Marques da Fonseca
Researcher at Federal University of Rio de Janeiro
Publications - 35
Citations - 388
Leonardo Marques da Fonseca is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 19 publications receiving 249 citations.
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Journal ArticleDOI
Metabolic Symbiosis and immunomodulation: How Tumor Cell-Derived Lactate May Disturb innate and Adaptive immune Responses
Alexandre Morrot,Alexandre Morrot,Leonardo Marques da Fonseca,Eduardo J. Salustiano,Luciana B. Gentile,Luciana Conde,Alessandra A. Filardy,Tatiany N. Franklim,Kelli Monteiro da Costa,Celio Geraldo Freire-de-Lima,Leonardo Freire-de-Lima +10 more
TL;DR: Recent advances regarding the deleterious effect of high concentrations of lactate on the tumor-infiltrating immune cells are discussed, which might characterize an innovative way of understanding the tumors-immune privilege.
Journal ArticleDOI
The trans-sialidase, the major Trypanosoma cruzi virulence factor: Three decades of studies
Leonardo Freire-de-Lima,Leonardo Marques da Fonseca,Thomas N. Oeltmann,Lucia Mendonça-Previato,J. O. Previato +4 more
TL;DR: The history of the discovery of T. cruzi-TS, as well as some well-documented biological effects encompassed by this parasite's virulence factor, an enzyme with potential attributes to become a drug target against Chagas disease are covered.
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Glycosylation in Cancer: Interplay between Multidrug Resistance and Epithelial-to-Mesenchymal Transition?
Leonardo Marques da Fonseca,Vanessa Amil da Silva,Leonardo Freire-de-Lima,José O. Previato,Lucia Mendonça-Previato,Marcia A. M. Capella +5 more
TL;DR: This review intends to compile the main facts obtained until now in epithelial-to-mesenchymal transition and multidrug resistance, as an effort to unravel the relationship between EMT and MDR.
Journal ArticleDOI
The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion.
Alexandra R. Assad,João M A Delou,Leonardo Marques da Fonseca,Nivaldo R. Villela,José Nascimento,Nubia Verçosa,Anibal Gil Lopes,Marcia A. M. Capella +7 more
TL;DR: Investigation of whether propofol induces renal preconditioning through renal KATP channels protected cells against apoptosis induced by ischemia-reperfusion (I-R), and protected LLC-PK1 from I-R-induced apoptosis.
Journal ArticleDOI
Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells.
Leonardo Marques da Fonseca,Lucas Rodrigues Jacques da Silva,Jhenifer Santos dos Reis,Marcos André Rodrigues da Costa Santos,Victoria de Sousa Chaves,Kelli Monteiro da Costa,Julliana de Nazareth Sa-Diniz,Celio Geraldo Freire de Lima,Alexandre Morrot,Alexandre Morrot,Tatiany N. Franklim,Douglas Chaves de Alcântara-Pinto,Marco Edilson Freire de Lima,José O. Previato,Lucia Mendonça-Previato,Leonardo Freire-de-Lima +15 more
TL;DR: Piperine might be further used in therapeutic strategies for metastatic cancer and EMT-related disorders, as well as its ability to inhibit E MT-related events induced by TGF-β1 treatment.