K
Kellie A. Brune
Researcher at Indiana University
Publications - 2
Citations - 346
Kellie A. Brune is an academic researcher from Indiana University. The author has contributed to research in topics: CD34 & GSK3B. The author has an hindex of 2, co-authored 2 publications receiving 336 citations.
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Lithium, a Common Drug for Bipolar Disorder Treatment, Regulates Amyloid-β Precursor Protein Processing
Yuan Su,John Ryder,Baolin Li,Xin Wu,Niles Fox,Pat Solenberg,Kellie A. Brune,Steven M. Paul,Yan Zhou,Feng Liu,Binhui Ni +10 more
TL;DR: It is reported that both lithium as well as valproic acid (VPA) inhibit beta-amyloid peptide (Abeta) production in HEK293 cells stably transfected with Swedish amyloid precursor protein (APP)(751) and in the brains of the PDAPP (APP(V717F)) Alzheimer's disease transgenic mouse model at clinically relevant plasma concentrations.
Journal ArticleDOI
Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20
Ling Liu,Chunjin Ding,Wei Zeng,Josef G. Heuer,Jonathan Wendell Tetreault,Timothy W. Noblitt,Giao Hangoc,Scott Cooper,Kellie A. Brune,Ganesh R. Sharma,Niles Fox,Scott W. Rowlinson,Danise Paige Rogers,Derrick Ryan Witcher,Peter K. Lambooy,Victor J. Wroblewski,James R. Miller,Hal E. Broxmeyer +17 more
TL;DR: IL-20 administration to normal mice significantly increased only multipotential progenitor cells, demonstrating that IL-20 significantly influences hematopoiesis, with specificity toward multipotentials progenitors, the first cytokine with such specificity identified.