K
Kembra L. Howdeshell
Researcher at National Institutes of Health
Publications - 37
Citations - 4750
Kembra L. Howdeshell is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Phthalate & In utero. The author has an hindex of 26, co-authored 37 publications receiving 4482 citations. Previous affiliations of Kembra L. Howdeshell include University of Missouri & North Carolina State University.
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Journal ArticleDOI
Exposure to bisphenol A advances puberty
Kembra L. Howdeshell,Andrew K. Hotchkiss,Kristina A. Thayer,John G. Vandenbergh,Frederick S. vom Saal +4 more
TL;DR: It is shown that exposing female mouse fetuses to an EEDC at a dose that is within the range typical of the environmental exposure of humans alters the postnatal growth rate and brings on early puberty in these mice.
Journal ArticleDOI
A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner
Kembra L. Howdeshell,Vickie S. Wilson,Johnathan Furr,Christy R. Lambright,Cynthia V. Rider,Chad R. Blystone,Andrew K. Hotchkiss,Leon Earl Gray +7 more
TL;DR: In this article, the authors characterized the dose-response effects of six individual phthalates (BBP, DBP, DEHP, diethyl hexyl phthalate [DEP], DiBP, DiBP and Dipentyl Phthalate (DPP) on testicular testosterone production following exposure of Sprague-Dawley rats on GD 8-18.
Journal ArticleDOI
Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra
Barry G. Timms,Kembra L. Howdeshell,Lesley Barton,Sarahann Bradley,Catherine A. Richter,Frederick S. vom Saal +5 more
TL;DR: In this paper, the effects of exposure to bisphenol A and estrogenic drugs on the number and size of dorsolateral prostate ducts and overall increase in prostate duct volume were investigated.
production in the Sprague Dawley rat in a cumulative, dose additive manner.
Kembra L. Howdeshell,Vickie S. Wilson,Johnathan Furr,Christy R. Lambright,V Cynthia,Chad R. Blystone,Andrew K. Hotchkiss,Leon Earl Gray +7 more
TL;DR: It is demonstrated that individual phthalates with a similar mechanism of action can elicit cumulative, dose additive effects on fetal testosterone production and pregnancy when administered as a mixture.
Journal ArticleDOI
Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals1
L. Earl Gray,Vickie S. Wilson,Tammy E. Stoker,Christy S. Lambright,Johnathan Furr,Nigel Noriega,Kembra L. Howdeshell,Gerald T. Ankley,Louis J. Guillette +8 more
TL;DR: Information is presented on the classes of environmental chemicals that display antiandrogenic and androgenic activities in vitro and in vivo and an insight into how exposure to mixtures these chemicals might behave in utero is provided.