K
Ken-ichi Obata
Publications - 2
Citations - 203
Ken-ichi Obata is an academic researcher. The author has contributed to research in topics: Angiogenesis & Internalization. The author has an hindex of 2, co-authored 2 publications receiving 192 citations.
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Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes
Hiroto Hatakeyama,Hidetaka Akita,Emi Ishida,Hashimoto Koichi,Hideo Kobayashi,Takanori Aoki,Junko Yasuda,Ken-ichi Obata,Hiroshi Kikuchi,Tatsuhiro Ishida,Hiroshi Kiwada,Hideyoshi Harashima +11 more
TL;DR: It appears that the enhanced antitumor activity of DXR-SIL[anti-MT1-MMP(Fab')] resulted from acceleration of cellular uptake of lioposomes owing to the incorporated antibody after extravasation from capillaries in tumor.
Journal ArticleDOI
In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP).
Kazutaka Atobe,Tatsuhiro Ishida,Emi Ishida,Kouichi Hashimoto,Hideo Kobayashi,Jyunko Yasuda,Takanori Aoki,Ken-ichi Obata,Hiroshi Kikuchi,Hidetaka Akita,Tomohiro Asai,Hideyoshi Harashima,Naoto Oku,Hiroshi Kiwada +13 more
TL;DR: It would be expected that DXR-SIL[anti-MT1-MMP(Fab')] may achieve direct tumor cell killing and indirect tumor cell kill via the destruction of the tumor endothelium in vivo, and this strategy may have the potential for overcoming some major limitations in conventional chemotherapy in vivo.