K
Kazutaka Atobe
Researcher at University of Tokushima
Publications - 4
Citations - 369
Kazutaka Atobe is an academic researcher from University of Tokushima. The author has contributed to research in topics: Cytotoxicity & Contamination. The author has an hindex of 3, co-authored 3 publications receiving 340 citations.
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Journal ArticleDOI
Accelerated blood clearance of PEGylated liposomes upon repeated injections: Effect of doxorubicin-encapsulation and high-dose first injection
TL;DR: It is reported that a first injection of PEGylated liposomes containing encapsulated DXR failed to induce the "accelerated blood clearance (ABC) phenomenon", and this findings suggest that encapsulation of DXR as well as a relatively high lipid dose abrogate the immune response against P EGylatedliposomes which is observed with the same liposome but without DXR and at low doses.
Journal ArticleDOI
Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes.
TL;DR: The results suggest the possibility that cytotoxicity induced by lipofection, accompanied by gene changes, could intrinsically exacerbate, attenuate or even mask the desired effects of gene-based therapy.
Journal ArticleDOI
In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP).
Kazutaka Atobe,Tatsuhiro Ishida,Emi Ishida,Kouichi Hashimoto,Hideo Kobayashi,Jyunko Yasuda,Takanori Aoki,Ken-ichi Obata,Hiroshi Kikuchi,Hidetaka Akita,Tomohiro Asai,Hideyoshi Harashima,Naoto Oku,Hiroshi Kiwada +13 more
TL;DR: It would be expected that DXR-SIL[anti-MT1-MMP(Fab')] may achieve direct tumor cell killing and indirect tumor cell kill via the destruction of the tumor endothelium in vivo, and this strategy may have the potential for overcoming some major limitations in conventional chemotherapy in vivo.
Journal ArticleDOI
Teratogenic Effects of Organohalogen Contaminants Extracted from Whale Bacon in a Whole-Rat-Embryo Culture System
Masaharu Akita,Osamu Kimura,Kazutaka Atobe,Tetsuya Endo,Shizuo Yamada,Koichi Haraguchi,Yoshihisa Kato +6 more
TL;DR: The results indicate that the organohalogen contaminants in whale bacon may be teratogenic in a dose-dependent manner, and further studies are necessary to determine the dose–effect relationship.