K
Ken Y. Chan
Researcher at Broad Institute
Publications - 2
Citations - 198
Ken Y. Chan is an academic researcher from Broad Institute. The author has contributed to research in topics: Transduction (genetics) & Tropism. The author has an hindex of 2, co-authored 2 publications receiving 86 citations.
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Journal ArticleDOI
Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids.
Qin Huang,Ken Y. Chan,Isabelle G. Tobey,Yujia Alina Chan,Tim Poterba,Christine L. Boutros,Alejandro B. Balazs,Richard Daneman,Jonathan M. Bloom,Cotton Seed,Benjamin E. Deverman +10 more
TL;DR: It is demonstrated that this newly discovered mode of AAV binding and transduction can occur independently of other known AAV receptors, and inform ongoing efforts to develop next-generation AAV vehicles for human CNS gene therapy.
Posted ContentDOI
Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
Qin Huang,Ken Y. Chan,Isabelle G. Tobey,Yujia Alina Chan,Tim Poterba,Christine L. Boutros,Alejandro B. Balazs,Richard Daneman,Jonathan M. Bloom,Cotton Seed,Benjamin E. Deverman +10 more
TL;DR: A genome-wide association study was conducted, and rapidly identified and verified LY6A as an essential receptor for the AAV-PHP.B vectors in brain endothelial cells, and this newly discovered mode of AAV binding and transduction is independent of other known AAV receptors and can be imported into different cell types to confer enhanced transduction by the A.V.B vector.