R
Richard Daneman
Researcher at University of California, San Diego
Publications - 71
Citations - 15414
Richard Daneman is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Blood–brain barrier & Angiogenesis. The author has an hindex of 33, co-authored 64 publications receiving 11509 citations. Previous affiliations of Richard Daneman include University of California, Berkeley & Stanford University.
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An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Ye Zhang,Kenian Chen,Steven A. Sloan,Mariko L. Bennett,Anja R. Scholze,Sean O'Keeffe,Hemali Phatnani,Paolo Guarnieri,Christine Caneda,Nadine Ruderisch,Shuyun Deng,Shane A. Liddelow,Chaolin Zhang,Richard Daneman,Tom Maniatis,Ben A. Barres,Jian Qian Wu +16 more
TL;DR: The authors' data provide clues as to how neurons and astrocytes differ in their ability to dynamically regulate glycolytic flux and lactate generation attributable to unique splicing of PKM2, the gene encoding the glycoleytic enzyme pyruvate kinase.
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The Blood–Brain Barrier
Richard Daneman,Alexandre Prat +1 more
TL;DR: Understanding how these different cell populations interact to regulate the barrier properties is essential for understanding how the brain functions during health and disease.
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Pericytes are required for blood–brain barrier integrity during embryogenesis
TL;DR: Pericytes regulate functional aspects of the blood–brain barrier, including the formation of tight junctions and vesicle trafficking in CNS endothelial cells, but inhibit the expression of molecules that increase vascular permeability and CNS immune cell infiltration.
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Development, maintenance and disruption of the blood-brain barrier
TL;DR: This Review highlights recently gained mechanistic insights into the development and maintenance of the blood-brain barrier (BBB), and discusses how BBB disruption can cause or contribute to neurological disease.
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A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila
TL;DR: Using the green fluorescent protein (GFP) as a mobile artificial exon carried by a transposable P-element, a protein trap system is developed in Drosophila and it is observed that the subcellular localization of the fusion protein corresponds to the described distribution of the endogenous protein.