Yujia Alina Chan

TL;DR: It is found that truncation fusions of yeast FIP1 analogous to those in cancer cause loss of function and that siRNA knockdown of FIP 1L1 in human cells increases DNA damage and chromosome breakage.

TL;DR: The genome-wide distribution of DNA:RNA hybrid prone loci in Saccharomyces cerevisiae is described by DNA: RNA immunoprecipitation (DRIP) followed by hybridization on tiling microarray, showing that DNA:RNAs hybrids preferentially accumulated at rDNA, Ty1 and Ty2 transposons, telomeric repeat regions and a subset of open reading frames (ORFs).

TL;DR: The pE-MAP approach provides a powerful strategy to understand other multifunctional machines at amino acid resolution and suggests that transcription rate is tuned to regulate multiple gene expression steps.

TL;DR: It is demonstrated that this newly discovered mode of AAV binding and transduction can occur independently of other known AAV receptors, and inform ongoing efforts to develop next-generation AAV vehicles for human CNS gene therapy.

TL;DR: How RNA-processing defects could destabilize genomes through mutagenic R-loop structures and by altering expression of genes required for genome stability are discussed.