K
Kenichi Inagaki
Researcher at Okayama University
Publications - 54
Citations - 1357
Kenichi Inagaki is an academic researcher from Okayama University. The author has contributed to research in topics: Bone morphogenetic protein & Bone morphogenetic protein 6. The author has an hindex of 21, co-authored 47 publications receiving 1248 citations.
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Journal ArticleDOI
TNF-α inhibits BMP-induced osteoblast differentiation through activating SAPK/JNK signaling
Tomoyuki Mukai,Fumio Otsuka,Hiroyuki Otani,Misuzu Yamashita,Koji Takasugi,Kenichi Inagaki,Masahiro Yamamura,Hirofumi Makino +7 more
TL;DR: Collectively, TNF-α elicits BMP-induced osteogenic inhibition by suppressing B MP-Smad signaling pathway, at least in part, through SAPK/JNK activation and Smad6 upregulation.
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Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway.
Misuzu Yamashita,Fumio Otsuka,Tomoyuki Mukai,Hiroyuki Otani,Kenichi Inagaki,Tomoko Miyoshi,Junko Goto,Masahiro Yamamura,Hirofumi Makino +8 more
TL;DR: Collectively, simvastatin supports BMP-induced osteoblast differentiation through antagonizing TNF-alpha-to-Ras/Rho/MAPK pathway and augmenting B MP-Smad signaling, suggesting a potential usage of statins to ameliorate inflammatory bone damage.
Journal ArticleDOI
Differential regulation of steroidogenesis by bone morphogenetic proteins in granulosa cells: involvement of extracellularly regulated kinase signaling and oocyte actions in follicle-stimulating hormone-induced estrogen production.
Tomoko Miyoshi,Fumio Otsuka,Kenichi Inagaki,Hiroyuki Otani,Masaya Takeda,Jiro Suzuki,Junko Goto,Toshio Ogura,Hirofumi Makino +8 more
TL;DR: Oocytes enhance FSH-induced MAPK activation and BMP signaling in granulosa cells, which leads to differential regulation of steroidogenesis elicited by BMPs in the presence of FSH in developing follicles.
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Novel action of activin and bone morphogenetic protein in regulating aldosterone production by human adrenocortical cells.
TL;DR: The present data suggest that activin acts to regulate adrenal aldosterone synthesis predominantly by modulating the ACTH-cAMP-protein kinase A signaling cascade, whereas BMP-6 works primarily bymodulating the Ang II-MAPK cascade in human adrenal cortex in an autocrine/paracrine fashion.
Journal ArticleDOI
Mutual Regulation of Follicle-Stimulating Hormone Signaling and Bone Morphogenetic Protein System in Human Granulosa Cells
Tomoko Miyoshi,Fumio Otsuka,Jiro Suzuki,Masaya Takeda,Kenichi Inagaki,Yoshihiro Kano,Hiroyuki Otani,Yukari Mimura,Toshio Ogura,Hirofumi Makino +9 more
TL;DR: Bone morphogenetic proteins play critical roles in folliculogenesis by modulating the actions of follicle-stimulating hormone (FSH) in the ovary and the two major factors, FSH-cAMP pathway and BMP system, are reciprocally and functionally linked.