K
Kenichiro Kojima
Researcher at Teikyo University
Publications - 22
Citations - 453
Kenichiro Kojima is an academic researcher from Teikyo University. The author has contributed to research in topics: Proteinuria & Glomerular basement membrane. The author has an hindex of 9, co-authored 21 publications receiving 357 citations. Previous affiliations of Kenichiro Kojima include Medical University of Vienna.
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Journal ArticleDOI
Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial
Kenjiro Kimura,Tatsuo Hosoya,Shunya Uchida,Masaaki Inaba,Hirofumi Makino,Shoichi Maruyama,Sadayoshi Ito,Tetsuya Yamamoto,Yasuhiko Tomino,Iwao Ohno,Yugo Shibagaki,Satoshi Iimuro,Naohiko Imai,Masanari Kuwabara,Hiroshi Hayakawa,Hiroshi Ohtsu,Yasuo Ohashi,Seiichi Matsuo,Hisashi Yamanaka,Tadao Akizawa,Tamio Teramoto,Hiroshi Kasanuki,Kenichi Yoshimura,Hiroshi Sato,Satoshi Horikoshi,Syoichi Maruyama,Masahiko Inaba,Yuji Moriwaki,Haruhito Uchida,Nagayuki Kaneshiro,Hidekazu Moriya,Yasuhiro Komatsu,Shinya Kaname,Kazunari Hanaoka,Makoto Ogura,Masato Ikeda,Kenji Kasai,Akira Sugiura,Kazushi Takahashi,Kenichiro Kojima,Kosaku Nitta,Hirofumi Tamai,Hiroshi Nagaya,Senji Okuno,Ryusuke Kakiya,Hiroya Takeoka,Kyouji Hirata,Kenichiro Asano,Yasuo Fukaya,Yasushi Iwaida,Yasuo Tsuneda,Shigeaki Nishimura,Takeyuki Hiramatsu,Yoshitaka Isaka,Takafumi Ito,Yukio Yuzawa,Kunihiro Yamagata,Tadashi Sofue,Yoshimi Jinguji,Keita Hirano,Kazuhiro Matsuyama,Teruhiko Mizumoto,Yuko Shibuya,Masahiro Sugawara,Moritoshi Kadomura,Yasuaki Teshima,Hiroshi Ohtani,Hiroki Kamata,Susumu Okawara,Masaki Fukushima,Katsumi Takemura,Eriko Kinugasa,Masami Kogure,Yoichi Ehara +73 more
TL;DR: Compared to placebo, febuxostat did not mitigate the decline in kidney function among patients with stage 3 CKD and asymptomatic hyperuricemia andSubgroup analysis demonstrated a significant benefit from febUXostat in patients without proteinuria and for whom serum creatinine concentration was lower than the median.
Journal ArticleDOI
Podocyte Flattening and Disorder of Glomerular Basement Membrane Are Associated with Splitting of Dystroglycan-Matrix Interaction
Kenichiro Kojima,Agnes Davidovits,Helga Poczewski,Brigitte Langer,Shunya Uchida,Katalyn Nagy-Bojarski,Anny Hovorka,Roland Sedivy,Dontscho Kerjaschki +8 more
TL;DR: Results indicate that both polycation and ROS induce similar changes in the distribution of podocyte alpha-dystroglycan that involve competitive disruption of alpha- dystroglcan/matrix protein complexes, endocytosis of the liberated receptor by podocytes, and disorganization of the matrix protein arrangement in the lamina rara externa of the GBM.
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Protection of α3 integrin-mediated podocyte shape by superoxide dismutase in the puromycin aminonucleoside nephrosis rat
TL;DR: It is suggested that alpha(3) integrin regulates glomerular permeability by maintaining podocyte shape and adhesion, which is disrupted by ROS overproduction.
Journal ArticleDOI
Association of cholesterol efflux capacity with plasmalogen levels of high-density lipoprotein: A cross-sectional study in chronic kidney disease patients.
Ryouta Maeba,Kenichiro Kojima,Michito Nagura,Aya Komori,Megumi Nishimukai,Tomoki Okazaki,Shunya Uchida +6 more
TL;DR: High plasmalogens concentrations in HDL may correlate with acceleration of cholesterol efflux and their decreased levels may promote atherosclerosis in advanced CKD patients.
Journal ArticleDOI
Defective glycosylation of α-dystroglycan contributes to podocyte flattening.
Kenichiro Kojima,Hitonari Nosaka,Yuki Kishimoto,Yuri Nishiyama,Seiichi Fukuda,Masaru Shimada,Kenzo Kodaka,Fumiaki Saito,Kiichiro Matsumura,Teruo Shimizu,Tatsushi Toda,Satoshi Takeda,Hiroshi Kawachi,Shunya Uchida +13 more
TL;DR: The results indicate that appropriate glycosylation of α-dystroglycan has an important role in the maintenance of podocyte architecture, as judged by immunohistochemistry and real-time RT-PCR.