D
Dontscho Kerjaschki
Researcher at Medical University of Vienna
Publications - 217
Citations - 27326
Dontscho Kerjaschki is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Lymphatic system & Podocyte. The author has an hindex of 84, co-authored 217 publications receiving 25166 citations. Previous affiliations of Dontscho Kerjaschki include French Institute of Health and Medical Research & Ewha Womans University.
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Journal ArticleDOI
Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium
Silvana Breiteneder-Geleff,Afschin Soleiman,Heinrich Kowalski,Reinhard Horvat,Gabriele Amann,Ernst Kriehuber,Katja Diem,Wolfgang Weninger,Erwin Tschachler,Kari Alitalo,Dontscho Kerjaschki +10 more
TL;DR: In this article, a light and electron microscopic immunohistochemistry (EMI) was used to detect podoplanin, a ∼38kd membrane glycoprotein of podocytes, specifically expressed in the endothelium of lymphatic capillaries, but not in the blood vasculature.
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Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism
Agnes Machnik,Wolfgang Neuhofer,Jonathan Jantsch,Anke Dahlmann,Tuomas Tammela,Katharina Machura,Joon-Keun Park,F. X. Beck,Dominik N. Müller,Wolfgang Derer,Jennifer Goss,Agata Ziomber,Peter Dietsch,Hubertus Wagner,Nico van Rooijen,Armin Kurtz,Karl F. Hilgers,Kari Alitalo,Kai-Uwe Eckardt,Friedrich C. Luft,Dontscho Kerjaschki,Jens Titze +21 more
TL;DR: It is shown that a high-salt diet in rats leads to interstitial hypertonic Na+ accumulation in skin, resulting in increased density and hyperplasia of the lymphcapillary network and VEGFC is identified as an osmosensitive, hypertonicity-driven gene intimately involved in salt-induced hypertension.
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Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3
Taija Makinen,Tanja Veikkola,Satu Mustjoki,Terhi Karpanen,Bruno Catimel,Edouard C. Nice,Lyn M. Wise,Andrew A. Mercer,Heinrich Kowalski,Dontscho Kerjaschki,Steven A. Stacker,Marc G. Achen,Kari Alitalo +12 more
TL;DR: It is shown that VEGFR‐3 stimulation alone protects the lymphatic endothelial cells from serum deprivation‐induced apoptosis and induces their growth and migration, and defines the critical role of VEGF‐C/VEG FR‐3 signalling in the growth and survival of lymphatichelial cells.
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Tumor-Associated Macrophages Express Lymphatic Endothelial Growth Factors and Are Related to Peritumoral Lymphangiogenesis
Sebastian F. Schoppmann,Peter Birner,Johannes Stöckl,Romana Kalt,Robert Ullrich,Carola Caucig,Ernst Kriehuber,Katalin Nagy,Kari Alitalo,Dontscho Kerjaschki +9 more
TL;DR: V EGF-C- and VEGF-D-expressing TAMs play a novel role in peritumoral lymphangiogenesis and subsequent dissemination in human cancer.
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Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor
Tatiana V. Petrova,Taija Makinen,Tomi P. Mäkelä,Janna Saarela,Ismo Virtanen,Robert E. Ferrell,David N. Finegold,Dontscho Kerjaschki,Seppo Ylä-Herttuala,Kari Alitalo +9 more
TL;DR: It is found that isolated human primary lymphatic and blood vascular endothelial cells show interesting differences in gene expression relevant for their distinct functions in vivo, and overexpression of the homeobox transcription factor Prox‐1 in the BECs is suggested to act as a cell proliferation inducer and a fate determination factor for the LECs.