K
Kenji Sugita
Publications - 15
Citations - 804
Kenji Sugita is an academic researcher. The author has contributed to research in topics: Gelatinase & Nedaplatin. The author has an hindex of 12, co-authored 15 publications receiving 775 citations.
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Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents.
Hiroshi Itazaki,Kazuo Nagashima,Kenji Sugita,Hiroshi Yoshida,Yoshimi Kawamura,Yukio Yasuda,Koichi Matsumoto,Kikuo Ishii,Nobuo Uotani,Hiroshi Nakai,Akihiro Terui,Shinya Yoshimatsu,Yuji Ikenishi,Yuzo Nakagawa +13 more
TL;DR: New cyclotetrapeptides, trapoxins A and B were isolated from the culture broth of Helicoma ambiens RF-1023 and exhibit detransformation activities against v-sis oncogene-transformed NIH3T3 cells (sis/NIH 3T3) as antitumor agents.
Journal Article
Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase.
Takayuki Yoshioka,Tohru Wada,Naomi Uchida,Hideo Maki,Hiroshi Yoshida,Nobuyuki Ide,Hisanori Kasai,Kanji Hojo,Kiniiyo Shono,Ryuji Maekawa,Shigeo Yagi,Robert M. Hoffman,Kenji Sugita +12 more
TL;DR: The data presented in this report indicate that rMETase is active alone, is synergistic in combination with 5-FU, and has negligible toxicity suggesting a novel clinical approach for effective cancer therapy.
Journal ArticleDOI
Molecular Cloning and Expression of the Mouse 105-kDa Gelatinase cDNA
TL;DR: A potent gelatinolytic activity in the culture supernatant of a metastatic tumor line, SN-H, derived from a murine squamous cell carcinoma, is detected and the cDNA of this gelatinase is cloned, confirming that this cDNA is functional.
Journal ArticleDOI
Antitumor efficacy of hypothemycin, a new Ras-signaling inhibitor.
TL;DR: It is found that hypothemycin, an anti‐bacterial, reduces RRE‐dependent transcription, and these findings suggest that hypot blasphemycin inhibits Ras‐mediated cellular signaling.
Journal Article
Correlation of antiangiogenic and antitumor efficacy of N-biphenyl sulfonyl-phenylalanine hydroxiamic acid (BPHA), an orally-active, selective matrix metalloproteinase inhibitor.
Ryuji Maekawa,Hideo Maki,Hiroshi Yoshida,Kanji Hojo,Hidekazu Tanaka,Tohru Wada,Naomi Uchida,Yukihiro Takeda,Hisanori Kasai,Hiroyuki Okamoto,Tsuzuki Hiroshige,Yoshikazu Kambayashi,Fumihiko Watanabe,Kenji Kawada,Ken-ichi Toda,Mitsuaki Ohtani,Kenji Sugita,Takayuki Yoshioka +17 more
TL;DR: Results indicate that selective MMP inhibition is correlated with antiangiogenic and antitumor efficacy and that the selective M MP inhibitor BPHA has therapeutic potential.