R
Robert M. Hoffman
Researcher at University of California, San Diego
Publications - 1178
Citations - 47921
Robert M. Hoffman is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 101, co-authored 1111 publications receiving 43463 citations. Previous affiliations of Robert M. Hoffman include University of California, Berkeley & University of Nebraska Medical Center.
Papers
More filters
Journal ArticleDOI
Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force
Katarina Wolf,Mariska te Lindert,Marina Krause,Stephanie Alexander,Joost te Riet,Amanda L. Willis,Robert M. Hoffman,Carl G. Figdor,Stephen J. Weiss,Peter Friedl +9 more
TL;DR: The physical limits of cell migration in dense porous environments are dependent upon the available space and the deformability of the nucleus and are modulated by matrix metalloproteinases, integrins and actomyosin function.
Journal ArticleDOI
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.
Clemens A. Schmitt,Jordan S. Fridman,Meng Yang,Soyoung Lee,Eugene Baranov,Robert M. Hoffman,Scott W. Lowe +6 more
TL;DR: It is shown that primary murine lymphomas also respond to chemotherapy by engaging a senescence program controlled by p53 and p16(INK4a), and mice bearing tumors capable of drug-induced senescENCE have a much better prognosis following chemotherapy than those harboring tumors with senescences defects.
Journal ArticleDOI
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
Mitomu Kioi,Hannes Vogel,Geoffrey M. Schultz,Robert M. Hoffman,Griffith R. Harsh,J. Martin Brown +5 more
TL;DR: A novel approach is suggested for the treatment of GBM: in addition to radiotherapy, the vasculogenesis pathway needs to be blocked, and this can be accomplished using the clinically approved drug AMD3100, a small molecule inhibitor of SDF-1/CXCR4 interactions.
Journal ArticleDOI
The multiple uses of fluorescent proteins to visualize cancer in vivo
TL;DR: This work has shown for the first time the ability to visualize the colour-coding of cancer cells growing in vivo and enabled the distinction of host from tumour with single-cell resolution.
Journal ArticleDOI
Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases
Meng Yang,Eugene Baranov,Ping Jiang,Fang-Xian Sun,Xiao-Ming Li,Lingna Li,Satoshi Hasegawa,Michael Bouvet,Maraya Al-Tuwaijri,Takashi Chishima,Hiroshi Shimada,A. R. Moossa,Sheldon Penman,Robert M. Hoffman +13 more
TL;DR: The simple, noninvasive, and highly selective imaging of growing tumors, made possible by strong GFP fluorescence, enables the detailed imaging of tumor growth and metastasis formation and should facilitate studies of modulators of cancer growth including inhibition by potential chemotherapeutic agents.