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Kenmin Wu
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 6
Citations - 1706
Kenmin Wu is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Immune system & Cancer. The author has an hindex of 4, co-authored 5 publications receiving 1086 citations. Previous affiliations of Kenmin Wu include Howard Hughes Medical Institute.
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Journal ArticleDOI
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.
Elham Azizi,Ambrose J. Carr,Ambrose J. Carr,George Plitas,Andrew E. Cornish,Catherine Konopacki,Sandhya Prabhakaran,Juozas Nainys,Juozas Nainys,Kenmin Wu,Vaidotas Kiseliovas,Vaidotas Kiseliovas,Manu Setty,Kristy Choi,Rachel M. Fromme,Phuong Dao,Peter T. McKenney,Peter T. McKenney,Ruby C. Wasti,Krishna Kadaveru,Linas Mazutis,Alexander Y. Rudensky,Dana Pe'er +22 more
TL;DR: A preprocessing pipeline, SEQC, and a Bayesian clustering and normalization method, Biscuit, are developed to address computational challenges inherent to single-cell data and support a model of continuous activation in T cells and do not comport with the macrophage polarization model in cancer.
Journal ArticleDOI
Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer.
George Plitas,Catherine Konopacki,Kenmin Wu,Paula D. Bos,Monica Morrow,Ekaterina V. Putintseva,Dmitriy M. Chudakov,Alexander Y. Rudensky +7 more
TL;DR: These studies suggest that targeting CCR8 for the depletion of tumor-resident Treg cells might represent a promising immunotherapeutic approach for the treatment of breast cancer.
Posted ContentDOI
Single-Cell Immune Map of Breast Carcinoma Reveals Diverse Phenotypic States Driven by the Tumor Microenvironment
Elham Azizi,Ambrose J. Carr,George Plitas,Andrew E. Cornish,Catherine Konopacki,Sandhya Prabhakaran,Juozas Nainys,Kenmin Wu,Vaidotas Kiseliovas,Manu Setty,Kristy Choi,Phuong Dao,Linas Mazutis,Alexander Y. Rudensky,Dana Pe'er +14 more
TL;DR: The results argue against discrete activation states in T cells and the polarization model of macrophage activation in cancer, with important implications for characterizing tumor-infiltrating immune cells.
Posted ContentDOI
Single-cell Map of Diverse Immune Phenotypes Driven by the Tumor Microenvironment
Elham Azizi,Ambrose J. Carr,Ambrose J. Carr,George Plitas,Andrew E. Cornish,Andrew E. Cornish,Catherine Konopacki,Catherine Konopacki,Sandhya Prabhakaran,Juozas Nainys,Juozas Nainys,Kenmin Wu,Kenmin Wu,Vaidotas Kiseliovas,Vaidotas Kiseliovas,Manu Setty,Kristy Choi,Rachel M. Fromme,Phuong Dao,Peter T. McKenney,Ruby C. Wasti,Krishna Kadaveru,Linas Mazutis,Linas Mazutis,Alexander Y. Rudensky,Alexander Y. Rudensky,Dana Pe'er +26 more
TL;DR: An immune map of breast cancer is created using single-cell RNA-seq data from 45,000 immune cells from eight breast carcinomas, as well as matched normal breast tissue, blood, and lymph node, to support a model of continuous activation in T cells and do not comport with the macrophage polarization model in cancer.
Journal ArticleDOI
Phase I/II study of mogamulizumab, an anti-CCR4 antibody targeting regulatory T cells in advanced cancer patients.
George Plitas,Kenmin Wu,Jeremie Carlson,Nicholas Cimaglia,Monica Morrow,Alexander Y. Rudensky,Jedd D. Wolchok +6 more
TL;DR: This data indicates that Treg-positive B cell reprograming acts as a “spatially aggregating force” to reprogram CD4 T cells to regulate immune homeostasis in mice with EMT.