K
Kenneth D. Brandt
Researcher at University of Kansas
Publications - 269
Citations - 33781
Kenneth D. Brandt is an academic researcher from University of Kansas. The author has contributed to research in topics: Osteoarthritis & Cartilage. The author has an hindex of 73, co-authored 269 publications receiving 32322 citations. Previous affiliations of Kenneth D. Brandt include Indiana University & Indiana University – Purdue University Indianapolis.
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Journal ArticleDOI
What is important in treating osteoarthritis? Whom should we treat and how should we treat them?
Paul Dieppe,Kenneth D. Brandt +1 more
TL;DR: The authors believe that future research in OA therapeutics should concentrate more on behavioral and physical interventions than on drugs, should examine packages of care involving combinations of treatment modalities, and should include a consideration of patient preferences.
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Lack of association between serum keratan sulfate concentrations and cartilage changes of osteoarthritis after transection of the anterior cruciate ligament in the dog.
TL;DR: Although the serum KS concentration was not helpful as an indicator of the current status of the articular cartilage abnormality in the OA knee, serial samples from 6 dogs showed an increase of at least 10% over the baseline KS level at both timepoints following surgery, which presumably reflects changes in proteoglycan metabolism in the unstable knee.
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Is knee radiography useful for studying the efficacy of a disease-modifying osteoarthritis drug in humans?
TL;DR: While the various standardization protocols described in this article perform with great success in short-term demonstrations of the reproducibility of positioning and radiographic JSW, differences clearly exist between protocols in the quality of performance over intervals relevant to clinical DMOAD trials.
Journal ArticleDOI
Putting Some Muscle into Osteoarthritis
TL;DR: Whether pharmacologic inhibition of collagenase or other MMPs would ameliorate cartilage breakdown in patients with osteoarthritis-and whether this inhibition can be accomplished without major adverse effects-remains to be determined.
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Procollagenase is reduced to inactive fragments upon activation in the presence of doxycycline.
TL;DR: It was shown that oral doxycycline administration slows the progression of cartilage destruction in osteoarthritis induced in dogs by anterior cruciate ligament, and inhibition of total collagenase was more pronounced than was inhibition of active enzyme.