K
Kenneth D. Brandt
Researcher at University of Kansas
Publications - 269
Citations - 33781
Kenneth D. Brandt is an academic researcher from University of Kansas. The author has contributed to research in topics: Osteoarthritis & Cartilage. The author has an hindex of 73, co-authored 269 publications receiving 32322 citations. Previous affiliations of Kenneth D. Brandt include Indiana University & Indiana University – Purdue University Indianapolis.
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Effects of tiaprofenic acid on the concentration and metabolism of proteoglycans in normal and degenerating canine articular cartilage.
TL;DR: The suppression of net cartilage proteoglycan synthesis caused by immobilization was not affected by administration of TPA nor did the drug affect the proportion of newly synthesized glycosaminoglycans recovered from the spent culture medium, suggesting that it did not increase proteogly can catabolism or affect the integrity of the cartilage matrix.
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Effects of salicylate on chondrocytes from osteoarthritic and contralateral knees of dogs with unilateral anterior cruciate ligament transection.
TL;DR: The results of this study show that, after isolation from the extracellular matrix, normal and OA chondrocytes in suspension culture are similarly susceptible to the metabolic effects of salicylate, however, chondROcytes from the contralateral knees of dogs with unilateral OA were notably resistant to the effects ofSalicylates.
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Erosive temporomandibular joint disease as a feature of the spondyloarthropathy of ulcerative colitis
Steven Eyanson,Steven Eyanson,Charles E. Hutton,Charles E. Hutton,Kenneth D. Brandt,Kenneth D. Brandt +5 more
TL;DR: Findings suggest that the temporomandibular joint disease in this case was a feature of the patient's spondylitis rather than a manifestation of the peripheral joint arthritis which commonly occurs in patients with ulcerative colitis.
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Joint effusions after kidney transplantation
TL;DR: Thirty-seven consecutive renal transplant recipients were studied prospectively for joint disease and benign transudative effusions did not correlate with immunologic abnormalities, transplant rejection, crystal deposition, or avascular necrosis and may have been due to high dose oral corticosteroid therapy.
Journal Article
Studies in animal models of osteoarthritis as predictors of a structure-modifying effect of diacerhein in humans with osteoarthritis
TL;DR: In addressing the use of animal models of osteoarthritis (OA) for predicting a structure-modifying effect of the anthraquinone derivative, diacerhein (DAR) in humans with OA, it is worth considering at the outset the context for the useof animal models, in general, as predictors of drug effects in humanswith OA.