Showing papers by "Kenneth M. Carpenter published in 2008"

Developing therapies for depression in drug dependence: results of a stage 1 therapy study.

Abstract: Objective: This Stage 1b controlled trial sought a preliminary test of the relative efficacy of Behavioral Therapy for Depression in Drug Dependence (BTDD) against a structured relaxation intervention (REL) for treating DSM-IV depressive disorders and substance abuse. Method: Thirty-eight methadone maintained opiate dependent participants, who met criteria for a DSM-IV depressive disorder, were randomized to one of two, 24-week treatment conditions (BTDD or REL). Results: Depression response, defined as at least a 50% reduction in Hamilton Depression Scale score from baseline to the end of study, was high and similar in both BTDD (61%) and REL (65%). Rates of drug use were low overall, both at baseline and at the end of study, and did not differ between treatment groups at study endpoint. Conclusions: The findings suggest that both behavioral- and relaxation-based approaches show promise for treating comorbid depression in drug dependent populations. Future work should examine combining or modifying these...