K
Kenneth W. Sommerville
Researcher at Duke University
Publications - 13
Citations - 776
Kenneth W. Sommerville is an academic researcher from Duke University. The author has contributed to research in topics: Opioid & Naltrexone Hydrochloride. The author has an hindex of 9, co-authored 13 publications receiving 589 citations. Previous affiliations of Kenneth W. Sommerville include Pfizer & Research Triangle Park.
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Journal ArticleDOI
Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial
Elizabeth A. Thiele,Eric D. Marsh,Jacqueline A French,Maria Mazurkiewicz-Bełdzińska,Selim R Benbadis,Charuta Joshi,Paul D Lyons,Adam Taylor,Claire Roberts,Kenneth W. Sommerville,Kenneth W. Sommerville,Boudewjin Gunning,Jacek Gawlowicz,Pawel Lisewski,Maria Mazurkiewicz Beldzinska,Krystyna Mitosek Szewczyk,Barbara Steinborn,Marta Zolnowska,Elaine Hughes,Ailsa McLellan,Selim R. Benbadis,Michael A. Ciliberto,Gary G. Clark,Dennis J. Dlugos,Francis Filloux,Robert Flamini,Jacqueline A. French,Michael Frost,Sheryl R. Haut,Siddarth Kapoor,Sudha Kilaru Kessler,Linda Laux,Paul D. Lyons,Eric D. Marsh,David Moore,Richard P. Morse,Venkatesh Nagaraddi,William E. Rosenfeld,Laurie E. Seltzer,Renée A. Shellhaas,Joseph Sullivan,Elizabeth A. Thiele,Liu Lin Thio,David Wang,Angus A. Wilfong +44 more
TL;DR: Add-on cannabidiol is efficacious for the treatment of patients with drop seizures associated with Lennox-Gastaut syndrome and is generally well tolerated.
Journal ArticleDOI
A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures.
Bassel Abou-Khalil,James W. Wheless,Joanne Rogin,Kevin Wolter,Glenn C. Pixton,Rajesh B. Shukla,Nancy Sherman,Kenneth W. Sommerville,Kenneth W. Sommerville,Veeraindar Goli,Veeraindar Goli,Carl L. Roland +11 more
TL;DR: The objective of this study was to evaluate the efficacy and safety of the diazepam AI when administered by caregivers to control an episode of ARS.
Journal ArticleDOI
Assessment of pharmacodynamic effects following oral administration of crushed morphine sulfate and naltrexone hydrochloride extended-release capsules compared with crushed morphine sulfate controlled-release tablets and placebo in nondependent recreational opioid users.
Beatrice Setnik,Kenneth W. Sommerville,Kenneth W. Sommerville,Veeraindar Goli,Veeraindar Goli,Ling Han,Lynn R. Webster +6 more
TL;DR: This study demonstrated that when crushed and administered orally to nondependent recreational opioid users, MSN was associated with significantly lower scores on all positive subjective measures including drug liking and high, and significantly less pupil constriction compared with crushed morphine sulfate CR.
Journal ArticleDOI
Safety and effectiveness of long-term treatment with diazepam auto-injector administered by caregivers in an outpatient setting for the treatment of acute repetitive seizures.
Joanne Rogin,James W. Wheless,Bassel Abou-Khalil,Kevin Wolter,Glenn C. Pixton,Nancy Sherman,Rajesh B. Shukla,Carl L. Roland,Kenneth W. Sommerville,Kenneth W. Sommerville +9 more
TL;DR: It is demonstrated that diazepam AI was well‐tolerated and significantly more effective than placebo AI in delaying the time to next seizure or rescue.
Journal ArticleDOI
A multicenter, primary care-based, open-label study to identify behaviors related to prescription opioid misuse, abuse, and diversion in opioid-experienced patients with chronic moderate-to-severe pain
Beatrice Setnik,Carl L. Roland,Kenneth W. Sommerville,Glenn C. Pixton,Robert Berke,Anne Calkins,Veeraindar Goli +6 more
TL;DR: More research is needed to better understand the gap between the investigator assessment of potential risk for misuse, abuse, and diversion and the actual extent of these behaviors among patients with chronic pain.