E
Eric D. Marsh
Researcher at Children's Hospital of Philadelphia
Publications - 138
Citations - 6767
Eric D. Marsh is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Epilepsy & Medicine. The author has an hindex of 33, co-authored 109 publications receiving 4973 citations. Previous affiliations of Eric D. Marsh include University of Pennsylvania & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
Orrin Devinsky,J. Helen Cross,Linda Laux,Eric D. Marsh,Ian Miller,Rima Nabbout,Ingrid E. Scheffer,Elizabeth A. Thiele,Stephen Wright +8 more
TL;DR: Among patients with the Dravet syndrome, cannabidiol resulted in a greater reduction in convulsive‐seizure frequency than placebo and was associated with higher rates of adverse events.
Journal ArticleDOI
Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial
Orrin Devinsky,Eric D. Marsh,Daniel Friedman,Elizabeth A. Thiele,Linda Laux,Joseph Sullivan,Ian Miller,Robert Flamini,Angus Wilfong,Francis Filloux,Matthew Wong,Nicole Tilton,Patricia L. Bruno,Judith Bluvstein,Julie Hedlund,Rebecca M. Kamens,Jane Maclean,Srishti Nangia,Nilika S. Singhal,Carey A Wilson,Anup D. Patel,Maria Roberta Cilio +21 more
TL;DR: The findings suggest that cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with highly treatment-resistant epilepsy.
Journal ArticleDOI
Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial
Elizabeth A. Thiele,Eric D. Marsh,Jacqueline A French,Maria Mazurkiewicz-Bełdzińska,Selim R Benbadis,Charuta Joshi,Paul D Lyons,Adam Taylor,Claire Roberts,Kenneth W. Sommerville,Kenneth W. Sommerville,Boudewjin Gunning,Jacek Gawlowicz,Pawel Lisewski,Maria Mazurkiewicz Beldzinska,Krystyna Mitosek Szewczyk,Barbara Steinborn,Marta Zolnowska,Elaine Hughes,Ailsa McLellan,Selim R. Benbadis,Michael A. Ciliberto,Gary G. Clark,Dennis J. Dlugos,Francis Filloux,Robert Flamini,Jacqueline A. French,Michael Frost,Sheryl R. Haut,Siddarth Kapoor,Sudha Kilaru Kessler,Linda Laux,Paul D. Lyons,Eric D. Marsh,David Moore,Richard P. Morse,Venkatesh Nagaraddi,William E. Rosenfeld,Laurie E. Seltzer,Renée A. Shellhaas,Joseph Sullivan,Elizabeth A. Thiele,Liu Lin Thio,David Wang,Angus A. Wilfong +44 more
TL;DR: Add-on cannabidiol is efficacious for the treatment of patients with drop seizures associated with Lennox-Gastaut syndrome and is generally well tolerated.
Journal ArticleDOI
GRIN2A mutation and early‐onset epileptic encephalopathy: personalized therapy with memantine
Tyler Mark Pierson,Hongjie Yuan,Eric D. Marsh,Karin Fuentes-Fajardo,David R. Adams,Thomas C. Markello,Gretchen Golas,Dimitre R. Simeonov,Conisha Holloman,Anel Tankovic,Manish M. Karamchandani,John M. Schreiber,James C. Mullikin,Cynthia J. Tifft,Camilo Toro,Cornelius F. Boerkoel,Stephen F. Traynelis,William A Gahl +17 more
TL;DR: Techniques of modern translational medicine are employed to identify a disease‐causing mutation, analyze its altered behavior, and screen for therapeutic compounds to treat the proband.
Journal ArticleDOI
Human and automated detection of high-frequency oscillations in clinical intracranial EEG recordings.
TL;DR: An HFO detector that improves upon existing algorithms, and performs as well as human experts on a test data set, and is useful for analyzing large EEG databases to determine the pathophysiological significance of HFO events in human epileptic networks.