Kenneth Weichert

TL;DR: The crystal structure of human PRMT5 in complex with MEP50, bound to an S-adenosylmethionine analog and a peptide substrate derived from histone H4 is determined and the structure of the surprising hetero-octameric complex reveals the close interaction between the seven-bladed β-propeller MEP50 and the N-terminal domain ofPRMT5, and delineates the structural elements of substrate recognition.

TL;DR: Genetic suppression screens identified enforcers of the spindle assembly checkpoint (SAC) as essential for LY3295668 cytotoxicity in Rb-deficient cancers and suggest a model in which a primed SAC creates a unique dependency on AurA kinase for mitotic exit and survival.

TL;DR: Molecular modeling is used to identify mutations in the TCR constant domains (Cα/Cβ) that increase the unfolding temperature of Cα-Cβ by 20 °C, improve the expression of four separate α/β TCRs by 3- to 10-fold, and improve the assembly and stability of T CRs with poor intrinsic stability.

TL;DR: Zhang et al. as mentioned in this paper determined the crystal structures of the antibody-BTLA complexes, showing that these antibodies bind distinct and non-overlapping epitopes of BTLA and showed the strongest agonistic activity in functional cell assays and in an imiquimod-induced mouse model of psoriasis.