Kentaro Semba

TL;DR: Its sequence shows that the c-erb-B-2 gene encodes a possible receptor protein and allows an analysis of the similarity of the protein to the EGF receptor and the neu product.

TL;DR: Southern blot analysis showed close similarity of the restriction patterns of the rat c-erbB-2 gene and the rat neu oncogene, suggesting possible involvement of c- Derbyshire-related DNA clones in human cancer.

TL;DR: Tyr-1472 phosphorylation of GluRε2 was greatly reduced infyn mutant mice and significantly enhanced after induction of long term potentiation in the hippocampal CA1 region, suggesting that Tyr-1336, Tyr-1252, and Tyr- 1472 in Glu Rε2 were phosphorylated in human embryonic kidney fibroblasts when co-expressed with active Fyn, and its magnitude became larger in murine brain.

TL;DR: Results are consistent with the hypothesis that, in A431 cells, gene amplification, possibly associated with a translocation event, may result in the overproduction of EGF receptor protein or the appearance of the transformed phenotype (or both).

TL;DR: The c-erbB-2 gene is a v-erb B-related proto-oncogene which is distinct from the gene encoding the epidermal growth factor receptor, and a specific breakpoint observed in a translocation associated with acute promyelocytic leukemia is mapped.