K
Kumao Toyoshima
Researcher at Osaka University
Publications - 84
Citations - 8673
Kumao Toyoshima is an academic researcher from Osaka University. The author has contributed to research in topics: Gene & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 36, co-authored 84 publications receiving 8570 citations. Previous affiliations of Kumao Toyoshima include University of Tokyo.
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Journal ArticleDOI
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.
Tadashi Yamamoto,Shuntaro Ikawa,Tetsu Akiyama,Tetsu Akiyama,Kentaro Semba,Nobuo Nomura,Nobuo Nomura,Nobuyuki Miyajima,Toshiyuki Saito,Kumao Toyoshima +9 more
TL;DR: Its sequence shows that the c-erb-B-2 gene encodes a possible receptor protein and allows an analysis of the similarity of the protein to the EGF receptor and the neu product.
Journal ArticleDOI
The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity.
TL;DR: Although the c-erbB-2 protein was predicted to encode a protein very similar to epidermal growth factor (EGF) receptor, EGF did not stimulate this kinase activity either in vivo or in vitro.
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A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma
TL;DR: Southern blot analysis showed close similarity of the restriction patterns of the rat c-erbB-2 gene and the rat neu oncogene, suggesting possible involvement of c- Derbyshire-related DNA clones in human cancer.
Journal ArticleDOI
Human immunodeficiency viruses.
John M. Coffin,Ashley T. Haase,Jay A. Levy,Luc Montagnier,Steven Oroszlan,Natalie M. Teich,Howard M. Temin,Kumao Toyoshima,Harold E. Varmus,Peter K. Vogt,Robin A. Weiss +10 more
TL;DR: HIV-1 RNA load testing is sometimes requested to resolve equivocal serologic findings or to facilitate the diagnosis of HIV-1 infection during the acute phase or in a pediatric setting.
Journal ArticleDOI
Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo.
J. Yokota,Kumao Toyoshima,Takashi Sugimura,Tadashi Yamamoto,Masaaki Terada,Hector Battifora,M.J. Cline +6 more
TL;DR: This paper showed that the amplified c-erbB-2 gene may have a role in the evolution of adenocarcinomas, as does the EGF receptor in some squamous-cell carcinomas.