K
Kerstin Bartscherer
Researcher at Max Planck Society
Publications - 29
Citations - 3229
Kerstin Bartscherer is an academic researcher from Max Planck Society. The author has contributed to research in topics: Regeneration (biology) & Planarian. The author has an hindex of 19, co-authored 26 publications receiving 2812 citations. Previous affiliations of Kerstin Bartscherer include German Cancer Research Center & Heidelberg University.
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Active Wnt proteins are secreted on exosomes
TL;DR: It is demonstrated that exosomes carry Wnts on their surface to induce Wnt signalling activity in target cells and an evolutionarily conserved functional role of extracellular vesicular transport of Wnt proteins is demonstrated.
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Secretion of Wnt ligands requires Evi, a conserved transmembrane protein.
TL;DR: It is suggested that evi is the founding member of a gene family specifically required for Wg/Wnt secretion, which is evolutionarily conserved as depletion of its human homolog disrupts Wnt signaling in human cells.
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Cell cycle control of wnt receptor activation.
Gary Davidson,Jinlong Shen,Ya Lin Huang,Yi Su,Emil Karaulanov,Kerstin Bartscherer,Christine Hassler,Peter Stannek,Michael Boutros,Christof Niehrs +9 more
TL;DR: Using a kinome-wide RNAi screen, it is shown that PPPSP phosphorylation requires the Drosophila Cyclin-dependent kinase (CDK) L63, and in Xenopus embryos, Cyclin Y is required in vivo for LRP6 phosphorylated, maternal Wnt signaling, and Wnt-dependent anteroposterior embryonic patterning.
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Smed-Evi/Wntless is required for β-catenin-dependent and -independent processes during planarian regeneration
TL;DR: This study provides evidence that planarian Wnts are major regulators of regeneration, and that they signal through β-catenin-dependent and -independent pathways.
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The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration.
TL;DR: Why planarians are an exciting tool in the study of regeneration and its underlying stem cell biology in vivo is highlighted, and the potential promises and current limitations of this model organism for stem cell research and regenerative medicine are discussed.