K
Keshari M. Thakali
Researcher at University of Arkansas for Medical Sciences
Publications - 50
Citations - 2092
Keshari M. Thakali is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Offspring & Vascular smooth muscle. The author has an hindex of 23, co-authored 46 publications receiving 1775 citations. Previous affiliations of Keshari M. Thakali include Arkansas Children's Hospital & University of Arizona.
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Journal ArticleDOI
Crystal Structure and Electron Transfer Kinetics of CueO, a Multicopper Oxidase Required for Copper Homeostasis in Escherichia coli
Sue A. Roberts,Andrzej Weichsel,Gregor Grass,Keshari M. Thakali,James T. Hazzard,Gordon Tollin,Christopher Rensing,William R. Montfort +7 more
TL;DR: Results suggest the methionine-rich helix blocks access to the T1 site in the absence of excess copper, and the trinuclear copper cluster has a conformation not previously seen.
Journal ArticleDOI
Maternal obesity is associated with a lipotoxic placental environment.
Jessica Saben,Forrest Lindsey,Ying Zhong,Keshari M. Thakali,Thomas M. Badger,Aline Andres,Horacio Gomez-Acevedo,Kartik Shankar +7 more
TL;DR: RNA-sequencing on term placenta from obese women indicates that maternal obesity leads to a lipotoxic placental environment that is associated with decreased regulators of angiogenesis and increased markers of inflammation and oxidative stress.
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Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations.
Umesh D. Wankhade,Ying Zhong,Ping Kang,Maria P. Alfaro,Sree V. Chintapalli,Keshari M. Thakali,Kartik Shankar +6 more
TL;DR: It is indicated that maternal HFD detrimentally alters epigenetic and gut microbiome pathways to favor development of fatty liver disease and its progressive sequelae.
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Linkage between Catecholate Siderophores and the Multicopper Oxidase CueO in Escherichia coli
Gregor Grass,Gregor Grass,Keshari M. Thakali,Phillip E. Klebba,Daniel Thieme,Axel Müller,Günter F. Wildner,Christopher Rensing +7 more
TL;DR: Evidence is provided that CueO protects E. coli cells by oxidizing enterobactin, the catechol iron siderophore of E. Escherichia coli, in the presence of copper.
Journal ArticleDOI
Bioactivities of açaí (Euterpe precatoria Mart.) fruit pulp, superior antioxidant and anti-inflammatory properties to Euterpe oleracea Mart.
Jie Kang,Keshari M. Thakali,Cheng-Hui Xie,Miwako Kondo,Yudong Tong,Boxin Ou,Gitte S. Jensen,Marjorie B. Medina,Alexander G. Schauss,Xianli Wu +9 more
TL;DR: In this paper, the antioxidant and anti-inflammatory activities of Euterpe oleracea precatoria (EP) fruit pulps were evaluated by different assays including a series of oxygen radical absorbance capacity (ORAC) based assays, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the cell-based antioxidant protection in erythrocyte (CAP-e), as well as the nuclear factor-kappa B (NF-jB) secreted embryonic alkaline phosphatase (SE