H
Horacio Gomez-Acevedo
Researcher at University of Arkansas for Medical Sciences
Publications - 38
Citations - 1049
Horacio Gomez-Acevedo is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 31 publications receiving 862 citations. Previous affiliations of Horacio Gomez-Acevedo include University of Alberta & Arkansas Children's Hospital.
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Journal ArticleDOI
Maternal obesity is associated with a lipotoxic placental environment.
Jessica Saben,Forrest Lindsey,Ying Zhong,Keshari M. Thakali,Thomas M. Badger,Aline Andres,Horacio Gomez-Acevedo,Kartik Shankar +7 more
TL;DR: RNA-sequencing on term placenta from obese women indicates that maternal obesity leads to a lipotoxic placental environment that is associated with decreased regulators of angiogenesis and increased markers of inflammation and oxidative stress.
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Maternal obesity enhances white adipose tissue differentiation and alters genome-scale DNA methylation in male rat offspring.
Sarah J. Borengasser,Ying Zhong,Ping Kang,Forrest Lindsey,Martin J. J. Ronis,Thomas M. Badger,Horacio Gomez-Acevedo,Kartik Shankar +7 more
TL;DR: The findings strongly suggest that the maternal OB in utero alters adipocyte commitment and differentiation via epigenetic mechanisms.
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High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring.
Sarah J. Borengasser,Ping Kang,Jennifer Faske,Horacio Gomez-Acevedo,Michael L. Blackburn,Thomas M. Badger,Kartik Shankar +6 more
TL;DR: It is indicated that offspring from obese rat dams have detrimental alternations to circadian machinery that may contribute to impaired liver metabolism in response to HFD, specifically via reduced PPARα expression prior to obesity development.
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Backward bifurcation in a model for HTLV-I infection of CD4+ T cells
TL;DR: A mathematical model for HTLV-I infection of CD4+ T cells that incorporates both horizontal and vertical transmission is considered and a backward bifurcation is considered which raises many new challenges to effective infection control.
Journal ArticleDOI
Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity
Jessica Saben,Ying Zhong,Horacio Gomez-Acevedo,Keshari M. Thakali,Sarah J. Borengasser,Aline Andres,Kartik Shankar +6 more
TL;DR: It is demonstrated that lipotoxic insults induce inflammation in placental cells via activation of JNK/EGR-1 signaling, and term placenta from obese women also had both increased JNK and p38 signaling and greater EGR-1 protein relative to lean women.