Maternal obesity is associated with a lipotoxic placental environment.
Jessica Saben,Forrest Lindsey,Ying Zhong,Keshari M. Thakali,Thomas M. Badger,Aline Andres,Horacio Gomez-Acevedo,Kartik Shankar +7 more
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TLDR
RNA-sequencing on term placenta from obese women indicates that maternal obesity leads to a lipotoxic placental environment that is associated with decreased regulators of angiogenesis and increased markers of inflammation and oxidative stress.About:
This article is published in Placenta.The article was published on 2014-03-01 and is currently open access. It has received 227 citations till now. The article focuses on the topics: Placenta & Lipotoxicity.read more
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Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child
TL;DR: Increased prepregnancy maternal insulin resistance and accompanying hyperinsulinemia, inflammation, and oxidative stress seem to contribute to early placental and fetal dysfunction in obese women.
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Inflammation in maternal obesity and gestational diabetes mellitus.
TL;DR: It is proposed that the placenta 'senses' and adapts to the maternal inflammatory environment, and plays a central role as both a target and producer of inflammatory mediators, and may indirectly program the fetus for later disease by influencing placental function.
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Maternal obesity and neurodevelopmental and psychiatric disorders in offspring
TL;DR: This review synthesizes human and animal data linking maternal obesity and high‐fat diet consumption to abnormal fetal brain development and neurodevelopmental and psychiatric morbidity in offspring and highlights key mechanisms by which maternal Obesity and maternal diet might impact fetal and offspring neurodevelopment.
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Pathophysiology and Current Clinical Management of Preeclampsia
TL;DR: This review will highlight factors implicated in the pathophysiology of preeclampsia and current treatments for the management of this disease.
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Angiogenesis in the placenta: the role of reactive oxygen species signaling.
Robyn D. Pereira,Nicole E. De Long,Ruijun C. Wang,Fereshteh T. Yazdi,Alison C. Holloway,Sandeep Raha +5 more
TL;DR: How oxidative stress observed in maternal smoking, maternal obesity, and preeclampsia has been associated with aberrant angiogenesis and placental dysfunction resulting in adverse pregnancy outcomes is discussed.
References
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A simple method for the isolation and purification of total lipides from animal tissues.
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
TL;DR: Bowtie extends previous Burrows-Wheeler techniques with a novel quality-aware backtracking algorithm that permits mismatches and can be used simultaneously to achieve even greater alignment speeds.
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AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
TL;DR: Although best known for its effects on metabolism, AMPK has many other functions, including regulation of mitochondrial biogenesis and disposal, autophagy, cell polarity, and cell growth and proliferation.
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FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.
Marieke A.G. Essers,Sanne Weijzen,Alida M.M. de Vries-Smits,Ingrid Saarloos,Nancy D de Ruiter,Johannes L. Bos,Boudewijn M.T. Burgering +6 more
TL;DR: A homeostasis mechanism for sustaining cellular reactive oxygen species that is controlled by signalling pathways that can convey both negative (PI‐3K/PKB) and positive (Ras/Ral) inputs is outlined.
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Stressing the role of FoxO proteins in lifespan and disease.
TL;DR: This work has shown that a shared yet opposing regulatory network between FoxO and p53 may underlie a 'trade-off' between disease and lifespan.