K
Keston Aquino-Michaels
Researcher at University of Chicago
Publications - 14
Citations - 4392
Keston Aquino-Michaels is an academic researcher from University of Chicago. The author has contributed to research in topics: Gene & Warfarin. The author has an hindex of 10, co-authored 14 publications receiving 3239 citations.
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Journal ArticleDOI
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Ayelet Sivan,Leticia Corrales,Nathaniel Hubert,Jason B. Williams,Keston Aquino-Michaels,Zachary M. Earley,Franco W. Benyamin,Yuk Man Lei,Bana Jabri,Maria-Luisa Alegre,Eugene B. Chang,Thomas F. Gajewski +11 more
TL;DR: Comparison of melanoma growth in mice harboring distinct commensal microbiota and observed differences in spontaneous antitumor immunity, suggests that manipulating the microbiota may modulate cancer immunotherapy.
Journal ArticleDOI
A Gene-Based Association Method for Mapping Traits Using Reference Transcriptome Data
Eric R. Gamazon,Heather E. Wheeler,Kaanan P. Shah,Sahar V. Mozaffari,Keston Aquino-Michaels,Robert J. Carroll,Anne E. Eyler,Joshua C. Denny,Dan L. Nicolae,Nancy J. Cox,Nancy J. Cox,Hae Kyung Im +11 more
TL;DR: The results demonstrate that PrediXcan can detect known and new genes associated with disease traits and provide insights into the mechanism of these associations.
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Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues
Heather E. Wheeler,Kaanan P. Shah,Jonathon Brenner,Tzintzuni Garcia,Keston Aquino-Michaels,Nancy J. Cox,Dan L. Nicolae,Hae Kyung Im +7 more
TL;DR: A systematic survey of the heritability and the distribution of effect sizes across all representative tissues in the human body and applies this knowledge to develop prediction models of gene expression traits for all tissues.
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The composition of the microbiota modulates allograft rejection
Yuk Man Lei,Luqiu Chen,Ying Wang,Andrew T. Stefka,Luciana Molinero,Betty Theriault,Keston Aquino-Michaels,Ayelet Sivan,Cathryn R. Nagler,Thomas F. Gajewski,Anita S. Chong,Caroline Bartman,Maria-Luisa Alegre +12 more
TL;DR: It is demonstrated that Abx pretreatment prolongs graft survival, suggesting that targeting microbial constituents is a potential therapeutic strategy for enhancing graft acceptance and alloimmunity is modulated by the composition of microbiota rather than the quantity of bacteria.
Journal ArticleDOI
Ethnicity-Specific Pharmacogenetics: The Case of Warfarin In African Americans
Wenndy Hernandez,Eric R. Gamazon,Keston Aquino-Michaels,Shitalben R. Patel,Travis J. O’Brien,Arthur F. Harralson,Arthur F. Harralson,Rick A. Kittles,April Barbour,Matthew Tuck,Samantha D. McIntosh,Samantha D. McIntosh,Jacqueline N. Douglas,Dan L. Nicolae,Larisa H. Cavallari,Minoli A. Perera +15 more
TL;DR: The first warfarin dosing algorithm that includes recently discovered polymorphisms in VKORC1 and CYP2C9 associated with warfar in African Americans AAs is developed and compared to the International Warfarin Pharmacogenetics Consortium (IWPC) dosing algorithms.