Cathryn R. Nagler

TL;DR: It is demonstrated that Indigenous spore-forming bacteria from the mouse and human microbiota promote 5-HT biosynthesis from colonic enterochromaffin cells (ECs), which supply 5- HT to the mucosa, lumen, and circulating platelets and elevating luminal concentrations of particular microbial metabolites increases colonic and blood5-HT in germ-free mice.

TL;DR: It is shown here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota, and this data support the development of novel adjunctive probiotic therapies to potentiate the induction of tolerance to dietary allergens.

TL;DR: The data suggest that EHCF+LGG promotes tolerance in infants with CMA, in part, by influencing the strain-level bacterial community structure of the infant gut.

TL;DR: It is demonstrated that intestinal bacteria are critical for regulating allergic responses to dietary antigens and suggest that interventions that modulate bacterial communities may be therapeutically relevant for food allergy.

TL;DR: The data reveal a critical role for WASP in nTreg cell function and implicate nT Reg cell dysfunction in the autoimmunity associated with WASP deficiency and reveal significant impaired homing to both mucosal and peripheral sites upon adoptive transfer into WT recipient mice.