K
Kevin Chang
Researcher at University of California, Berkeley
Publications - 1
Citations - 526
Kevin Chang is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Cas9 & DNA repair. The author has an hindex of 1, co-authored 1 publications receiving 368 citations.
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Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
Kunwoo Lee,Michael J. Conboy,Hyo Min Park,Fuguo Jiang,Hyun Jin Kim,Hyun Jin Kim,Mark A. DeWitt,Vanessa A Mackley,Kevin Chang,Anirudh Rao,Colin M. Skinner,Tamanna Shobha,Melod Mehdipour,Hui Liu,Wen Chin Huang,Freeman Lan,Nicolas Bray,Song Li,Jacob E. Corn,Kazunori Kataoka,Jennifer A. Doudna,Irina M. Conboy,Niren Murthy +22 more
TL;DR: It is demonstrated that a delivery vehicle composed of gold nanoparticles conjugated to DNA and complexed with cationic endosomal disruptive polymers can deliver Cas9 ribonucleoprotein and donor DNA into a wide variety of cell types and efficiently correct the DNA mutation that causes Duchenne muscular dystrophy in mice via local injection, with minimal off-target DNA damage.