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Kevin D. Bunting
Researcher at Case Western Reserve University
Publications - 62
Citations - 5921
Kevin D. Bunting is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 29, co-authored 60 publications receiving 5747 citations. Previous affiliations of Kevin D. Bunting include St. Jude Children's Research Hospital & American Red Cross.
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Journal ArticleDOI
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Sheng Zhou,John D. Schuetz,Kevin D. Bunting,Anne-Marie Colapietro,Janardhan Sampath,John J. Morris,Irina Lagutina,Gerard Grosveld,Mitsujiro Osawa,Hiromitsu Nakauchi,Brian P. Sorrentino +10 more
TL;DR: Results show that expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources.
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Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells
Richard Moriggl,David J. Topham,Stephan Teglund,Veronika Sexl,Catriona McKay,Demin Wang,Angelika Hoffmeyer,Jan M. van Deursen,Mark Y. Sangster,Kevin D. Bunting,Gerard Grosveld,James N. Ihle,James N. Ihle +12 more
TL;DR: It is demonstrated that, while lymphoid development is normal, Stat5a/b mutant peripheral T cells are profoundly deficient in proliferation and fail to undergocell cycle progression or to express genes controlling cell cycle progression.
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ABC Transporters as Phenotypic Markers and Functional Regulators of Stem Cells
TL;DR: Regulation of stem cell biology by ABC transporters has emerged as an important new field of investigation and it will be critical to further characterize this family of proteins in hematopoietic lineage‐restricted stem cells and in pluripotent stem cells capable of crossing lineage barriers.
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Direct and Differential Suppression of Myeloid-Derived Suppressor Cell Subsets by Sunitinib Is Compartmentally Constrained
Jennifer S. Ko,Patricia Rayman,Joanna Ireland,Shadi Swaidani,Geqiang Li,Kevin D. Bunting,Brian I. Rini,James H. Finke,Peter A. Cohen +8 more
TL;DR: It is concluded that compartment-dependent GM-CSF exposure in resistant tumors may account for the regionalized effect of sunitinib upon host MDSC modulation and hypothesize that ancillary strategies to decrease such regionalized escape will enhance the potency of sun itinib as an immunomodulator and a cancer therapy.
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Stat5 tetramer formation is associated with leukemogenesis
Richard Moriggl,Veronika Sexl,Lukas Kenner,Christopher Duntsch,Katharina Stangl,Sebastien Gingras,Angelika Hoffmeyer,Anton Bauer,Roland P. Piekorz,Demin Wang,Kevin D. Bunting,Erwin F. Wagner,Karoline Sonneck,Peter Valent,James N. Ihle,Hartmut Beug +15 more
TL;DR: A constitutively activated Stat5a mutant, cS5F, was introduced into murine bone marrow cells and tetramers were found to accumulate in excess compared to dimer levels in various human leukemias, suggesting that Stat5 tetramer are associated with leukesmogenesis.