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Irina Lagutina
Researcher at St. Jude Children's Research Hospital
Publications - 12
Citations - 3454
Irina Lagutina is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: PAX3 & Alveolar rhabdomyosarcoma. The author has an hindex of 8, co-authored 8 publications receiving 3305 citations.
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The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Sheng Zhou,John D. Schuetz,Kevin D. Bunting,Anne-Marie Colapietro,Janardhan Sampath,John J. Morris,Irina Lagutina,Gerard Grosveld,Mitsujiro Osawa,Hiromitsu Nakauchi,Brian P. Sorrentino +10 more
TL;DR: Results show that expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources.
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An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Jeffrey T. Wigle,Jeffrey T. Wigle,Natasha L. Harvey,Michael Detmar,Irina Lagutina,Gerard Grosveld,Michael D. Gunn,David A. Jackson,Guillermo Oliver +8 more
TL;DR: It is proposed that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.
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Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors.
TL;DR: It is concluded that the Pax3-FKHR allele causes lethal developmental defects in knock-in mice but might be insufficient to cause muscle tumors.
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Modeling of the human alveolar rhabdomyosarcoma Pax3-Foxo1 chromosome translocation in mouse myoblasts using CRISPR-Cas9 nuclease.
Irina Lagutina,Virginia Valentine,Fabrizio Picchione,Frank C. Harwood,Marcus B. Valentine,Barbara Villarejo-Balcells,Jaime J. Carvajal,Gerard Grosveld +7 more
TL;DR: It is proposed that CRISPR-Cas9 provides a novel means to faithfully model human diseases caused by chromosome translocation in mice via spatial proximity of the Pax3 and Foxo1 loci in myoblasts of mice.
Journal ArticleDOI
Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.
Jordan M. Blum,Leonor Añó,Zhizhong Li,David Van Mater,Brian D. Bennett,Mohit Sachdeva,Irina Lagutina,Minsi Zhang,Jeffrey K. Mito,Leslie G. Dodd,Diana M. Cardona,Rebecca D. Dodd,Nerissa Williams,Yan Ma,Christoph Lepper,Corinne M. Linardic,Sayan Mukherjee,Gerard Grosveld,Chen-Ming Fan,David G. Kirsch +19 more
TL;DR: Results suggest that RMS and UPS have distinct and overlapping cells of origin within the muscle lineage, and established mouse models of soft tissue sarcoma from muscle stem and progenitor cells.